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Xanthine OxidaseThe enzyme xanthine oxidase, or XO, (bovine milk enzyme is PDB 1FIQ, EC 1.1.3.32) catalyzes the oxidation of hypoxanthine to xanthine and can further catalyze the oxidation of xanthine to uric acid: - hypoxanthine + O2 <-> xanthine + H2O2
- xanthine + O2 + 2H2O <-> uric acid + 2H2O2
The protein is large, having a molecular weight of 270,000, and has 2 flavin molecules (bound as FAD), 2 molybdenum atoms, and 8 iron atoms bound per enzymatic unit. In humans, xanthine oxidase is normally found in the liver and not free in the blood. During severe liver damage, xanthine oxidase is released into the blood, so a blood assay for XO is a way to determine if liver damage has happened. As well, because xanthine oxidase is a metabolic pathway for uric acid formation, the xanthine oxidase inhibitor allopurinol is used in the treatment of gout.
|  | william moulton marston
istro romanian language
beckenham (constituency)
megleno romanian language
kelly osbourne
coenzyme q
pedro zamora
sun ra
nammu
citation
an (mythology)
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annuna
captain marvel (marvel comics)
bucket sort
sidney bechet
flag of san marino
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tommy ladnier
san marino (disambiguation)
spontaneous music ensemble
bromley & chislehurst (constituency)
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kid ory
caesar the geezer
lewisham deptford (constituency)
execution by burning
die hard
democratic centralism
winn parish, louisiana
west feliciana parish, louisiana
west carroll parish, louisiana
west baton rouge parish, louisiana
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washington parish, louisiana
vernon parish, louisiana
vermilion parish, louisiana
union parish, louisiana
terrebonne parish, louisiana
tensas parish, louisiana
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michael collins (astronaut)
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