Other Definitions
vincristine (dict)

Vincristine

bgcolor="#ffffff" align="center" colspan="2" | Vincristine chemical structure
Vincristine
align="center" colspan="2" | 22-oxovincaleukoblastine
CAS number
57-22-7 & 28379-27-3		 ATC code
L01CA02
bgcolor="#eeeeee" | Chemical formula bgcolor="#ddeeff" | CHNO
bgcolor="#eeeeee" | Molecular weight bgcolor="#ddeeff" | 824.9
bgcolor="#eeeeee" | Metabolism bgcolor="#ddeeff" | ?
bgcolor="#eeeeee" | Elimination half life bgcolor="#ddeeff" | ?
bgcolor="#eeeeee" | Excretion bgcolor="#ddeeff" | ?
bgcolor="#eeeeee" | Pregnancy category bgcolor="#ddeeff" | ?
bgcolor="#eeeeee" | Legal status bgcolor="#ddeeff" | N/A
bgcolor="#eeeeee" | Delivery bgcolor="#ddeeff" | Intravenous solution
Vincristine (Oncovin®) is an alkaloid from the Madagascar Periwinkle (Catharanthus roseus, formerly Vinca Rosea and hence its name). It is used in chemotherapy.

Mode of action

Vincristine acts by binding to tubulin, the main protein of the cytoskeleton. Microtubule disruption impedes mitosis in metaphase. The vinca alkaloids therefore affect all rapidly dividing cell types, such as intestinal epithelium.

Side-effects

The main side-effects of vincristine are peripheral neuropathy and constipation. The latter may require laxatives, while the former can be a reason to reduce the dose of vincristine.

Uses

Vincristine is used in various types of chemotherapy regimens for tumours such as multiple myeloma (VAD regimen), acute myelogenous leukemia, lymphomas, breast cancer and lung cancer.

History

Having been used as a folk remedy for centuries, the C. roseus turned out to have 70 alkaloids in the 1950. Many are biologically active.

External links

 

<< PreviousWord BrowserNext >>
sura (disambiguation)
robert earnshaw
hotel rwanda
kings mills, ohio
difference of two squares
zopiclone
rifai
dog days (album)
1979 world series
semi professional
volcanic arc
modern pentathlon at the 2004 summer olympics men's
tamim al jundi
ninian park
enduring love
walkers
nitrazepam
eleazer d. wood
early decision
half r
tilghman tucker
john allen (soldier)
albert g. brown
rex allen
sinaia monastery
wojciech h. zurek
list of multi threading libraries
mary jayne gold
james whitfield (mississippi)
jimmie johnson
approaches to distinguishing religion from non religion
zoya kosmodemyanskaya
prittlewell square
a rock and roll alternative
marcel carn
abd allah ibn abd al muttalib
subskimmer
pinball illusions
gabrielle ray
three legged bird
the wire (television)
the wire (magazine)
birling gap
charles clark