State> | gcolor="#cccccc"|Incumbent | bgcolor="#cccccc"|Party | bgcolor="#cccccc"|Status | bgcolor="#cccccc"|Opposing Candidates |
| a href="/encyclopedia/Alabama" title="Alabama">Alabama | John Sparkman | Democrat | Re-elected, 82.5 - 17.5 | J. Foy Guin, Jr. (Republican) |
| a href="/encyclopedia/Arkansas" title="Arkansas">Arkansas | John L. McClellan | Democrat | Re-elected, unopposed | |
| a href="/encyclopedia/California" title="California">California1 | Thomas H. Kuchel | Republican | Re-elected, 53.2 - 45.5 | Samuel W. Yorty (Democrat) |
| a href="/encyclopedia/Colorado" title="Colorado">Colorado | Edwin C. Johnson | Democrat | Retired: Republican victory, 51.3 - 48.7 | Gordon Allott (Republican) John A. Carroll (Democrat) |
| a href="/encyclopedia/Delaware" title="Delaware">Delaware | J. Allen Frear, Jr. | Democrat | Re-elected, 56.9 - 43.1 | Herbert B. Warburton (Republican) |
| a href="/encyclopedia/Georgia-(U.S.-state)" title="Georgia (U.S. state)">Georgia | Richard Russell, Jr. | Democrat | Re-elected, unopposed | |
| a href="/encyclopedia/Idaho" title="Idaho">Idaho | Henry C. Dworshak | Republican | Re-elected, 62.8 - 37.2 | Glen H. Taylor (Democrat) |
| a href="/encyclopedia/Illinois" title="Illinois">Illinois | Paul Douglas | Democrat | Re-elected, 53.6 - 46.4 | Joseph T. Meek (Republican) |
| a href="/encyclopedia/Iowa" title="Iowa">Iowa | Guy M. Gillette | Democrat | Defeated, 52.2 - 47.5 | Thomas E. Martin (Republican) |
| a href="/encyclopedia/Kansas" title="Kansas">Kansas | Andrew F. Schoeppel | Republican | Re-elected, 56.3 - 41.8 | George McGill (Democrat) |
| a href="/encyclopedia/Kentucky" title="Kentucky">Kentucky | John S. Cooper | Republican | Defeated, 54.5 - 45.5 | Alben W. Barkley (Democrat) |
| a href="/encyclopedia/Louisiana" title="Louisiana">Louisiana | Allen J. Ellender | Democrat | Re-elected, unopposed | |
| a href="/encyclopedia/Maine" title="Maine">Maine | Margaret C. Smith | Republican | Re-elected, 58.6 - 41.4 | Paul A. Fullam (Democrat) |
| a href="/encyclopedia/Massachusetts" title="Massachusetts">Massachusetts | Leverett Saltonstall | Republican | Re-elected, 50.5 - 49.0 | Foster Furcolo (Democrat) |
| a href="/encyclopedia/Michigan" title="Michigan">Michigan | Homer Ferguson | Republican | Defeated, 50.8 - 48.9 | Patrick V. McNamara (Democrat) |
| a href="/encyclopedia/Minnesota" title="Minnesota">Minnesota | Hubert H. Humphrey | Democrat | Re-elected, 56.4 - 42.1 | Val Bjornson (Republican) |
| a href="/encyclopedia/Mississippi" title="Mississippi">Mississippi | James O. Eastland | Democrat | Re-elected, unopposed | |
| a href="/encyclopedia/Montana" title="Montana">Montana | James E. Murray | Democrat | Re-elected, 50.4 - 49.6 | Wesley A. D'Ewart (Republican) |
| a href="/encyclopedia/Nebraska" title="Nebraska">Nebraska2 | Samuel W. Reynolds | Republican | Retired: Republican victory, 60.9 - 39.1 | Roman L. Hruska (Republican) James F. Green (Democrat) |
| a href="/encyclopedia/Nebraska" title="Nebraska">Nebraska | Hazel H. Abel | Republican | Retired: Republican victory, 61.1 - 38.9 | Carl T. Curtis (Republican) Keith Neville (Democrat) |
| a href="/encyclopedia/Nevada" title="Nevada">Nevada3 | Ernest S. Brown | Republican | Defeated, 58.1 - 41.9 | Alan Bible (Democrat) |
| a href="/encyclopedia/New-Hampshire" title="New Hampshire">New Hampshire | Styles Bridges | Republican | Re-elected, 60.2 - 39.8 | Gerard L. Morin (Democrat) |
| a href="/encyclopedia/New-Hampshire" title="New Hampshire">New Hampshire4 | Robert W. Upton | Republican | Defeated in primary: Republican victory, 60.2 - 39.8 | Norris Cotton (Republican) Stanley J. Betley (Democrat) |
| a href="/encyclopedia/New-Jersey" title="New Jersey">New Jersey | Robert C. Hendrickson | Republican | Retired: Republican victory, 48.7 - 48.5 | Clifford P. Case (Republican) Charles R. Howell (Democrat) |
| a href="/encyclopedia/New-Mexico" title="New Mexico">New Mexico | Clinton P. Anderson | Democrat | Re-elected, 57.3 - 42.7 | Edwin L. Mechem (Republican) |
| a href="/encyclopedia/North-Carolina" title="North Carolina">North Carolina | Alton Asa Lennon | Democrat | Defeated in primary: Democrat victory, 65.9 - 34.1 | William Kerr Scott (Democrat) Paul C. West (Republican) |
| a href="/encyclopedia/North-Carolina" title="North Carolina">North Carolina5 | Sam Ervin | Democrat | Re-elected, unopposed | |
| a href="/encyclopedia/Ohio" title="Ohio">Ohio6 | Thomas A. Burke | Democrat | Defeated, 50.1 - 49.9 | George H. Bender (Republican) |
| a href="/encyclopedia/Oklahoma" title="Oklahoma">Oklahoma | Robert S. Kerr | Democrat | Re-elected, 55.8 - 43.7 | Fred M. Mock (Republican) |
| a href="/encyclopedia/Oregon" title="Oregon">Oregon | Guy Cordon | Republican | Defeated, 50.2 - 49.8 | Richard L. Neuberger (Democrat) |
| a href="/encyclopedia/Rhode-Island" title="Rhode Island">Rhode Island | Theodore F. Green | Democrat | Re-elected, 59.3 - 40.7 | Walter I. Sundlun (Republican) |
| a href="/encyclopedia/South-Carolina" title="South Carolina">South Carolina | Burnet R. Maybank | Democrat | Retired: Democrat victory, 63.1 - 36.8 | Strom Thurmond (Democrat) Edgar A. Brown (Democrat) |
| a href="/encyclopedia/South-Dakota" title="South Dakota">South Dakota | Karl E. Mundt | Republican | Re-elected, 57.3 - 42.7 | Kenneth Holum (Democrat) |
| a href="/encyclopedia/Tennessee" title="Tennessee">Tennessee | Estes Kefauver | Democrat | Re-elected, 70.0 - 30.0 | Tom Wall (Republican) |
| a href="/encyclopedia/Texas" title="Texas">Texas | Lyndon B. Johnson | Democrat | Re-elected, 84.7 - 14.8 | Carlos G. Watson (Republican) |
| a href="/encyclopedia/Virginia" title="Virginia">Virginia | A. Willis Robertson | Democrat | Re-elected, 79.9 - 10.7 - 9.4 | Charles W. Lewis, Jr. (Independent) Clarke T. Robb (Independent) |
| a href="/encyclopedia/West-Virginia" title="West Virginia">West Virginia | Matthew M. Neely | Democrat | Re-elected, 54.8 - 45.2 | Thomas Sweeney (Republican) |
| a href="/encyclopedia/Wyoming" title="Wyoming">Wyoming | Edward D. Crippa | Republican | Retired: Democrat victory, 51.5 - 48.5 | Joseph C. O'Mahoney (Democrat) William H. Harrison (Republican)
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