Transcription Factor

Classes

• General transcription factors are involved in the formation of a preinitiation complex.
• Upstream transcription factors are unregulated proteins that bind somewhere upstream of the initiation site to stimulate or repress transcription.
• Inducible transcription factors are similar to upstream transcription factors but require activation or inhibition.

Motifs found in transcription factors

• Helix-turn-helix (HTH) bind the major groove of the DNA.
• Zinc fingers function as structural platforms for DNA binding.
• Leucine zippers function in associating the transcription factors with each other.

See also

• DNA-binding protein

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