thrombopoietin

Thombopoietin is the recently discovered glycoprotein hormone that regulates the production of platelets. Before its identification, its function has been hypothesized for as much as 30 years as being linked to the cell surface receptor c-mpl, and in older publications thrombopoietin is described as c-mpl ligand (the agent that binds to the c-mpl molecule).

Function and regulation

Thombopoietin regulates the differentiation of megakaryocytes and platelets. Its negative feedback is different from most hormones in endocrinology: the effector regulates the hormone directly. Thrombopoeitin is bound to the surface of platelets, thereby reducing megakaryocyte exposure to the hormone.

Genetics

The thrombopoietin gene is located on the long arm of chromosome 3 (q26.3-27). Abnormalities in this gene occur in some hereditary forms of thrombocytosis (high platelet count) and in some cases of leukemia.

External link

<< Previous

Word Browser

Next >>

jamie lynn discala
university radio nottingham
rantoul
metacity
ranunculus
lorraine bracco
megakaryocyte
mississippi river (disambiguation)
mississippi river (ontario)
la bottine souriante
species diversity

andrei zhdanov
ecosystem diversity
elston howard
north tipperary
wessex society
munio de zamora
perth andover, new brunswick
south tipperary
michael imperioli
santa clara river
carnet

philae lander
tsa
grand canyon of the yellowstone
billy bailey
wooster (disambiguation)
monier monier williams
technology student association
dav stefnsson
self destruct
clique (graph theory)
adrien de gerlache

grand river (ontario)
jn thoroddsen
gold box
tony sirico
crow creek
fort william historical park
no way out
independent set
cuban prime
west melbourne
dominic chianese