Thapsigargin
Thapsigargin
is a tightly-binding
inhibitor
of a class of
enzymes
known by the acronym SERCA, which stands for sarco /
endoplasmic reticulum
Ca 2+
ATPase
.
Structurally,
thapsigargin is classified as a
sesquiterpene lactone
, and is extracted from a plant,
Thapsia Garganica
. It is a tumor promoter in mammalian cells, though, interestingly, it is also the target of the newer
artemesinin
derived anti-
malarial
drugs.
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