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Sidney W. FoxSidney W. Fox (24 March 1912 - 10 August 1998) was a Los Angeles-born biochemist. Education and early career Fox completed his undergraduate studies in chemistry at UCLA. After a brief stint working as a technician for Max Bergmann at the Rockefeller Institute, he returned to California to complete a PhD at Caltech. During Fox's studies at Caltech, he worked with Hugh Huffman, T.H. Morgan, and as a postdoc under Linus Pauling. During World War II, Fox participated in work to isolate vitamin A from shark livers; the compound was used to enhance the night vision of pilots. In 1941 he established a protein chemistry laboratory at the University of Michigan medical school; in 1942 he researched fish meal protein for an Oakland company. Professor In 1943 Fox was granted his first academic position at Iowa State College. In 1955 Fox assumed the directorship of the Oceanographic Institute at Florida State University. Shortly thereafter he published–with Joseph Foster—his first textbook. Beginning in 1964, Fox served as director of the Institute of Molecular Evolution at the University of Miami. During this time, his laboratory was involved in studying some of the first moon rocks brought back by the Apollo missions. After more than three decades in Florida, Fox moved to Southern Illinois University in 1989, and then on to the University of South Alabama in 1993. Microspheres Arguably Sidney Fox's best-known research was conducted in the 1950s and 1960s, when he studied the spontaneous formation of protein structures. His early work demonstrated that under certain conditions amino acids could spontaneously form small polypeptides—the first step on the road to the assembly of large proteins. The result was signficant because his experimental conditions duplicated conditions that might plausibly have existed early in Earth's history. Further work revealed that these amino acids and small peptides could be encouraged to form close spherical membranes, called microspheres. Fox has gone so far as to describe these formations as protocells, because he believed they might be an important intermediate step in the origin of life. Microspheres might have served as a stepping stone between simple organic compounds and genuine living cells. Family In 1937, Fox married Raia Joffe; they remained together until his death. They have three sons: Lawrence, Ronald, and Thomas. Publications - Sidney W. Fox and Joseph F. Foster. Introduction to Protein Chemistry. Wiley, 1957.
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