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ReelinReelin is a protein found in the brain. Its name comes from the abnormal reeling gait of reeler mice, which were found to have a deficiency of this brain protein and were homozygous for the reelin gene. Heterozygous mice for the reelin gene had very little obvious neuroanatomical defect but those that they had resembled the changes of the human schizophrenic brain. A special stain for the reelin protein showed a similar pattern of reelin deficiency in heterozygotic reeler mice, and also in biopsies of brains of pyschotic patients. Research into its functions and the causes and clinical effects of deficiencies is continuing.
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