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MesalaminePentasa (TM) Mesalazine is one of the newer Aminosalicylates, a class of drug used as an anti-inflammatory. Indication: treatment of mild to moderate ulcerative collitis and Crohn's disease (intestinal infammatory conditions) Mesalazine is a bowel specific drug, that is metabolized in the gut and has its predominant actions there- thereby having fewer systemic side effects. Mesalamine, also known as 5-aminosalicylic acid (5-ASA), is an anti-inflammatory drug used to treat inflammation of the rectum, mild to moderate ulcerative colitis and inflammation of the lower colon. Chemically, it is 5-amino-2-hydroxybenzoic acid. The empirical formula is C 7 H 7 NO 3 and its molecular weight is 153.14. It is sold in the U.S. under the names: Known side effects - Cramping
- Sudden severe stomach pain
- Bloody diarrhea
- Fever
- Severe headache
- Rash
- Nausea
- Hepatic impairment
- Agranulocytosis,Aplastic anaemia, Neutropenia, Thrombocytopenia- any sore throats, bruising or excesssive bleeding should be reported to the prescribing physician and a Full blood count (rbc and wbc) as well as liver function test be performed
- Myocarditis
- Methaeoglobinaemia
Dosing depends on preparation- the UK guidelines from the British National Formulary are: Asacol: 400mg tablets- 6 tablets daily for an acute attack, tablets for prophylaxis. Not recommended for children NB- preparations that lower stool pH (such as lactulose, a laxative) will affect the binding of Mesalazine in the bowel and will therfore reduce its efficacy. Pentasa 4g daily for an acute attack, 1.5g daily for prohpylaxis Sources for more information- British National Formulary, Davidsons Practice of Medicine, Oxford Textbook of Medicine, any other text book of medicine-
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