| Mayor !! Term !! Party |
| Alpheus P. Hodges | July 1, 1850 - May 7, 1851 (One term) |
| Benjamin D. Wilson | May 7, 1851 - May 4, 1852 (One term) |
| John G. Nichols | May 4, 1852 - May 3, 1853 (One term) |
| Antonio F. Coronel | May 3, 1853 - May 4, 1854 (One term) |
| Stephen C. Foster | May 4, 1854 - January 13, 1855 (One term) |
| (none) | January 13, 1855 - January 25, 1855 |
| Stephen C. Foster | January 25, 1855 - May 9, 1855 (Partial term) |
| Dr. Thomas Foster | May 9, 1855 - May 7, 1856 (One term) |
| Stephen C. Foster | May 7, 1856 - September 22, 1856 (Partial term) |
| Manuel Requena | September 22, 1856 - October 4, 1856 President, Acting Mayor |
| John G. Nichols | October 4, 1856 - May 9, 1859 (Three terms) |
| Damien Marchessault | May 9, 1859 - May 9, 1860 (One term) |
| Henry Mellus | May 9, 1860 - December 26, 1860 |
| William Woodworth | December 27, 1860 - January 7, 1861 President, Acting Mayor |
| Damien Marchessault | January 7, 1861 - May 6, 1865 (Four terms) |
| Jose Marcarel | May 5, 1865 - May 10, 1866 (One term) |
| Christobal Aguilar | May 10, 1866 - December 7, 1868 (Two terms) |
| Joel Turner | December 9, 1868 - December 9, 1870 (Two terms) |
| Christobal Aguilar | December 9, 1870 - December 5, 1872 (Two terms) |
| J. R. Toberman | December 5, 1872 - December 18, 1874 (Two terms) |
| Prudent Beaudry | December 18, 1874 - December 8, 1876 (Two terms) |
| Frederick A. MacDougal | December 8, 1876 - November 16, 1878 (Two terms) |
| Bernard Cohn | November 21, 1878 - December 5, 1878 (Partial term) |
| J. R. Toberman | December 5, 1878 - December 9, 1882 (Four terms) |
| Cameron E. Thom | December 9, 1882 - December 9, 1884 (Two terms) |
| Edward F. Spence | December 9, 1884 - December 14, 1886 (Two terms) |
| W. H. Workman | December 14, 1886 - December 10, 1888 (Two terms) |
| John Bryson | December 10, 1888 - February 25, 1889 (One term) |
| Henry T. Hazard | February 25, 1889 - December 5, 1892 (Two terms) |
| William H . Bonsall | December 5, 1892 - December 12, 1892 President, Acting Mayor |
| Thomas E. Rowan | December 12, 1892 - December 12, 1894 (One term) |
| Frank Rader | December 12, 1894 - December 16, 1896 (One term) |
| Meredith P. Snyder | December 16, 1896 - December 15, 1898 (One term) |
| Fred Eaton | December 15, 1898 - December 12, 1900 (One term) |
| Meredith P. Snyder | December 12, 1900 - December 8, 1904 (Two terms) |
| Owen McAleer | December 8, 1904 - December 13, 1906 (One term) |
| Arthur C. Harper | December 13, 1906 - March 11, 1909 (One term) |
| William D. Stephens | March 15, 1909 - March 26, 1909 | Republican |
| George Alexander | March 26, 1909 - July 1913 (Two terms) |
| Henry Rose | July 1913 - July 1915 (One term) |
| Charles E. Sebastian | July 1915 - September 2, 1916 (One term) |
| Frederick T. Woodman | September 5, 1916 - July 1919 (Two terms) |
| Meredith P. Snyder | July 1919 - July 1921 (One term) |
| George E. Cryer | July 1921 - July 1929 (Three terms) |
| John C. Porter | July 1929 - July 1933 (One term) |
| Frank L. Shaw | July 1933 - September 26, 1938 (Two terms) |
| Fletcher Bowron | September 26, 1938 - June 30, 1953 (Four terms) | Democratic |
| C. Norris Poulson | July 1, 1953 - June 30, 1961 (Two terms) | Republican |
| Samuel W. Yorty | July 1, 1961 - June 30, 1973 (Three terms) | Democratic |
| Thomas Bradley | July 1, 1973 - June 30, 1993 (Five terms) | Democratic |
| Richard J. Riordan | July 1, 1993 - June 30, 2001 (Two terms) | Republican |
| James K. Hahn | July 1, 2001 - Present | Democratic |