Product> | Character | Years used | Notes | | A&W Root Beer | The Great Root Bear | debuted 1974 | |
| AFLAC insurance | the AFLAC duck | 2000–present | voiced by Gilbert Gottfried |
| Ajax cleanser | the Ajax pixies | 1948–1950s | |
| Ajax detergent | the White Knight | debuted 1963 | |
| Alka-Seltzer | Speedy Alka-Seltzer | 1952–1964 | |
| American Tourister luggage | luggage-mauling gorilla | 1970–1980s | |
| Anderson's Soup | the Anderson's Soup twins Happy and Pee-Wee | debuted 1957 | voiced by Bob Elliott and Ray Goulding |
| Arby's | Oven Mitt | 2003–present | voiced by Tom Arnold |
| Aunt Jemima pancake mix and syrup | Aunt Jemima | 1893–present | |
| Bacardi Rum & Cola drink | Bacardi & Cola | 2003 | |
| Bardahl auto engine additive | Dirty Sludge, Sticky Valve, Gummy Ring, Blackie Carbon | 1953 | |
| Bartles & Jaymes wine coolers | Frank Bartles and Ed Jaymes | 1985–1991 | played by David Joseph Rufkahr (Bartles) and Dick Maugg (Jaymes) |
| Bob's Big Boy restaurants | Big Boy | | |
| Bonny Maid floor cover products | the Bonny Maid | 1949–1950 | played by Anne Francis |
| Boo Berry cereal | Boo Berry | | |
| Borden | Elsie the cow | 1938–present | |
| Bounty paper towels | Rosie the waitress | 1970–1990 | played by Nancy Walker |
| Bubble Yum bubble gum | Floyd D. Duck | | |
| Bud Ice beer | Bud Ice penguin | 1996 | known for ominously singing "Doo-be-doo-be-doo..." |
| Bud Light beer | Spuds McKenzie | 1987–1989 | |
| Bud Light beer | Johnny, the Bud Light guy | 1995 | known for catchphrase "I love you, ma-a-a-n!"; played by Rob Roy Fitzgerald |
| Budweiser beer | "Budweiser"-croaking frogs | 1990s | |
| Budweiser beer | Frank and Louie, lizards | 1998 | |
| Burger King restaurants | Herb | 1985 | played by John Merrick |
| Burger King restaurants | Fighting chickens Spicy and TC | 2004 | |
| California Raisin Advisory Board | the California Raisins | debuted 1987 | |
| Camel cigarettes | Joe Camel | 1987–1997 | |
| Campbell's Soup | the Campbell's Soup kids | | |
| Cap'n Crunch cereal | Cap'n Horatio Crunch | 1963–present | |
| Carling Black Label beer | Mabel the waitress | 1950s | played by Jean Goodspeed (1951 through mid-1950s) |
| Charmin bathroom tissue | Mr. Whipple | 1965–1989 | played by Dick Wilson |
| Chef Boyardee canned pastas | Chef Boyardee | | based on company founder Hector Boiardi |
| Cheetos snacks | Chester Cheetah | | |
| Chevron (Standard Oil of California) | Hy Finn | debuted 1958 | voiced by Paul Ford |
| Chevron | the Chevron cars | 1995–present | |
| Chick-fil-A | the Chick-fil-A cows | 1995–present | known for the catchphrase "Eat Mor Chikin" (sic) |
| Chicken of the Sea tuna | Chicken of the Sea mermaid | 1952–present | voiced by Darla Hood in TV commercials |
| Chiquita bananas | Miss Chiquita Banana | 1944–present | |
| Chuck E. Cheese restaurants | Chuck E. Cheese | 1977–present | |
| Cocoa Puffs cereal | Sonny the Cuckoo Bird | 1960s–present | |
| Comet cleanser | Josephine the plumber | 1960s–1970s | played by Jane Withers |
| Cookie Crisp cereal | Cookie Jarvis | 1970s | |
| Cookie Crisp cereal | Officer Krum, Cookie Crisp Crook, and Chip the Cookie Hound | 1990s | |
| Cool Whip dessert topping | Sarah Tucker | 1960s | played by Marge Redmond |
| Coppertone sunscreens | the Coppertone Girl | 1959–present | |
| Count Chocula cereal | Count Chocula | | |
| Cracker Jack snacks | Sailor Jack and his dog, Bingo | 1918–present | |
| Crest toothpaste | Arthur Goodwin, pharmacist | 1970s | played by Arthur O'Connell |
| Dell computers | Steven Jackson | 2000–2003 | known for quotes like "Dude, you got a Dell"; played by Benjamin Curtis |
| Diet Coke | Diet Coke hunk | 1990s | played by Lucky Vanous |
| Domino's Pizza | The Noid | 1980s–1990s | voiced by Pons Maar |
| Doublemint gum | Doublemint Twins | | |
| Dreyfus investments | Major, the Dreyfus lion | debuted 1960s | |
| Dunkin' Donuts | Fred the baker | 1981–1997 | known for quote "Time to make the donuts"; played by Michael Vale |
| Duracell batteries | The Puttermans | 1990s | |
| Dutch Boy paint | the Dutch boy | 1907–present | |
| Energizer batteries | Energizer Bunny | 1989–present | |
| Esso Oil/Exxon | the Esso tiger/the Exxon tiger | debuted 1964 | |
| Eveready batteries | Eveready "9 lives" cat | debuted c. 1920s–1930s | |
| Excalibur Films | Virginia Beaver | | Fictional spokesperson |
| Federal Express | Mr. Spleen, fast-talking executive | 1982 | played by John Moschitta, Jr. |
| Florida Department of Citrus | Florida Orange Bird | 1970s | created by Walt Disney Productions |
| Flying "A" service stations | Axelrod the dog | 1960s | |
| Ford automobiles | the Ford dog | debuted 1952 | |
| Franken Berry cereal | Franken Berry | | |
| Fritos snacks | Frito Bandito | 1960s | voiced by Mel Blanc |
| GEICO | the GEICO gecko | 1999–present | voiced by Dave Kelly, Richard Steven Horvitz, and others; now is considered voiceless. |
| General Mills | Betty Crocker | 1921–present | |
| Gerber baby products | the Gerber baby | 1927–present | |
| Gillette Blue Blade razors | Sharpie the parrot | 1952–1960 | |
| Good & Plenty candy | Choo-Choo Charlie | 1950–1950s | |
| Green Giant vegetables | Jolly Green Giant | 1928–present | | |
| Green Giant vegetables | Little Squirt | | |
| Hamburger Helper | the Helping Hand | debuted 1977 | voiced by Patrick Coyle |
| Hamm's Beer | Hamm's Beer bear | debuted 1952 | |
| Hawaiian Punch drink | Punchy (the Hawaiian Punch Guy), and Oaf/Opie | debuted 1961 | |
| The Hartford insurance | the Hartford elk | debuted 1974 | |
| Honey Nut Cheerios cereal | BuzzBee the bee | | |
| Hotpoint appliances | Happy Hotpoint | debuted 1955 | played by Mary Tyler Moore |
| Hubba Bubba bubble gum | the Hubba-Bubba Gum Fighter | debuted 1979 | |
| ICEE frozen drinks | ICEE polar bear | | |
| Ipana toothpaste | Bucky Beaver | 1950s | |
| Isuzu automobiles | Joe Isuzu | 1986–1990 | played by David Leisure |
| Italian Swiss Colony wine | Little old winemaker | 1960s | played by Ludwig Stossel, voiced by Jim Backus |
| Jack in the Box restaurants | Jack, the antenna ball-headed man | | |
| Jell-O gelatin | Chinese baby | debuted 1959 | voiced by Alan Swift |
| Keds shoes | Kedso the Clown | | |
| Keds shoes | Kolonel Keds | | |
| Keebler snacks | Ernie Keebler and the Keebler elves | 1968–present | |
| Kellogg's Froot Loops cereal | Toucan Sam | 1952–present | |
| Kellogg's Frosted Flakes cereal | Tony the Tiger | | voiced by Dallas McKennon, Thurl Ravenscroft |
| Kellogg's Pop-Tarts | Milton the Toaster | 1970s–1980s | voiced by William Schallert |
| Kellogg's Rice Krispies cereal | Snap, Crackle and Pop | 1928–present | |
| Kellogg's Smacks cereal | Dig 'Em Frog | 1972–present | |
| Kellogg's Sugar Pops cereal | Sugar Pops Pete | 1950s | |
| KFC restaurants | Colonel Sanders | | Col. Harland Sanders founded Kentucky Fried Chicken and eventually became its mascot; a later cartoon version was voiced by Randy Quaid |
| Kleenex table napkins | Manners the butler | 1957–1950s | played by Richard Cutting |
| Kools cigarettes | Willie the Kool penguin | debuted 1930s | Has a wife named Millie |
| Kool-Aid drink mix | Kool-Aid Man | 1975–present | |
Kraft Singles cheese | Dairy Fairy | debuted 1980s | | | Lee dungarees | Buddy Lee doll | 1998–present | based on the Buddy Lee character who debuted in 1921 |
| Life | Mikey, the freckled-face kid | 1972–1981 | played by John Gilchrist |
| Little Caesar's pizza | Little Caesar | | |
| Lucky Charms cereal | Lucky the leprechaun | | |
| M&M's candy | Red and Yellow M&M's characters | 1996–present | |
| M&M's candy | Blue and Green M&M's characters | 1997–present | |
| Mad magazine | Alfred E. Newman | 1954–present | |
| Marlboro cigarettes | the Marlboro Man | debuted 1954 | |
| Mattel toys | Matty Mattel | | |
| Maypo | Marky Maypo | 1950s | |
| Maytag appliances | Ol' Lonely, the Maytag repairman | debuted 1967 | played by Jesse White (1967–1988), Gordon Jump (1988–2003), Hardy Rawls (2003–present) |
| McDonald's | Ronald McDonald | 1963–present | |
| Meow Mix cat food | Meow Mix Cat | 1972–present | |
| Merrill Lynch | Merrill the bull | | |
| Metro-Goldwyn-Mayer | Leo the lion | | |
| Michelin | Bibendum (the Michelin Man) | 1898–present | |
| Mobil | Pegasus | 1911–present | |
| Morton Salt | the Morton Salt Girl | 1914–present | |
| Mr. Clean cleaning products | Mr. Clean | 1958–present | first live-action Mr. Clean played by House Peters, Jr. |
| Mrs. Butterworth's syrup | Mrs. Butterworth | | |
| National Crime Prevention Council | McGruff the Crime Dog | 1978–present | |
| National Federation of Coffee Growers | Juan Valdez | 1959–present | played by Jos F. Duval (1959–1969, Carlos Snchez (1969–present) |
| National Highway Traffic Safety Administration | Vince and Larry, the crash test dummies | 1985–1999 | |
| NBC | NBC peacock | 1956–1975, 1979-present | First appeared in 1956. Debuted as animated logo in 1957 |
| Nestl Quik/NesQuik | the Quik Bunny/NesQuik Bunny | 1973–present | |
| 9 Lives cat food | Morris the Cat | 1968–present | voiced by John Irwin |
| Old Milwaukee beer | the Swedish Bikini Team | 1991 | |
| Old Spice cologne and aftershave | the Old Spice sailor | 1970s–1980s | played by John Perry |
| Palmolive dish detergent | Madge the manicurist | 1966–1992 | played by Jan Miner |
| Pep Boys auto parts stores | Manny, Moe, and Jack | | |
| Pets.com | Pets.com Sock Puppet | | originally performed by Michael Ian Black; now mascot for auto loan company Bar None |
| Piels beer | Bert and Harry, the Piels brothers | 1955–1960 | voiced by Bob Elliott (Harry) and Ray Goulding (Bert) |
| Pillsbury | Poppin' Fresh, the Pillsbury Doughboy | | |
| Planters peanuts and snacks | Mr. Peanut | 1916–present | |
| Popsicle ice pops | Popsicle Pete | 1940s–1995 | |
| Post Sugar Crisp cereal | Sugar Bear | | voiced by Sterling Holloway |
| Qantas Airlines | Qantas koala bear | debuted 1967 | |
| Quaker Oats | the Quaker Oats man | 1877–present | |
| Quaker Quake cereal | Quake | 1965–1970s | |
| Quaker Quisp cereal | Quisp | 1965–1970s | |
| Quizno's | Spongmonkey | 2003–2004 | characters originated on an internet blog |
| Quizno's | Baby Bob | 2005–present | character originated on an internet blog, and had a short-lived CBS show; currently voiced by Ken Hudson Campbell |
| Raid insecticides | Raid bugs | 1956–present | |
| RCA | Nipper the dog | | |
| RCA | Chipper | debuted 1990s | |
| Robert Hall clothing stores | Robert Hall birds | 1950s | |
| Savarin coffee | El Exigente | 1960s–1970s | played by Carlos Montalbn |
| Schlitz Malt Liquor | Schlitz Malt Liquor bull | | |
| ScotTowels paper towels | Aunt Bluebelle | 1970s | voiced by Mae Questel |
| Scrubbing Bubbles bathroom cleaner | Scrubbing Bubbles | | |
| Serta mattresses | Serta Counting Sheep | | |
| 7up soda | Freshup Freddie | 1950s | |
| 7up soda | The 7Up Spot | 1987–1995 | |
| Snuggle fabric softener | Snuggle Bear | | |
| Star-Kist tuna | Charlie the Tuna | debuted 1961 | voiced by Herschel Bernardi |
| Starbucks coffee | the Starbucks melusine | | |
| Taco Bell | the Taco Bell chihuahua | 1997–2000 | voiced by Carlos Alazraqui |
| Taster's Choice coffee | Taster's Choice couple | debuted 1987 in Britain, 1990 in U.S. | played by Anthony Stewart Head and Sharon Maughan |
| Toys "R" Us stores | Geoffrey the giraffe | 1970s–present | animatronic Geoffrey voiced by Jim Hanks |
| Travelocity | the roaming garden gnome | debuted 2003 | |
| Trix cereal | Trix rabbit | | |
| Trojan condoms | Trojan Man | | |
| Twinkies snacks | Twinkie the Kid | | |
| Ty-D-Bowl toilet cleaners | the Ty-D-Bowl Man | | played by Mark Matheisen, Fred Miltonberg, Larry Sprinkle |
| Uncle Ben's rice | Uncle Ben | | Named after an actual Texas rice grower named Uncle Ben from years earlier |
| United States Forest Service | Smokey Bear | 1944–present | |
| United States Forest Service | Woodsy Owl | 1970–present | |
| United States Post Office Department / United States Postal Service | Mr. ZIP | 1960s–1970s | |
| Vlasic pickles | the Vlasic stork | | |
| Wendy's Restaurants | Mr. Wendy | debuted 2004 | played by Roger Eschbacher |
| Western Airlines | Wally the bird | debuted 1955 | |
| Xerox copiers | Brother Dominick | debuted 1975 | played by Jack Eagle |
| various advertisers | Ernest P. Worrell | debuted 1980s | played by Jim Varney |