Ketanserin
Ketanserin
Chemical name
-
Chemical formula
C
22
H
22
FN
3
O
3
Molecular mass
395.43 g/mol
CAS number
74050-98-9
SMILES
O=C(C4=CC=C(F)C=C4)C(CC3)CCN3
CCN(C2=O)C(NC1=C2C=CC=C1)=O
chemical structure of ketanserin
Ketanserin
is a
serotonin receptor
antagonist
. It has the highest
affinity
for the
serotonin
5-HT
2A
receptor
, but also
binds
less potently to the 5-HT
2C
, 5-HT
2B
, 5-HT
1D
,
alpha-adrenergic
, and
dopamine
receptors. With
tritium
radioactively
labeled ketanserin is used as a
radioligand
for the serotonin 5-HT
2A
receptor, e.g. in
receptor binding assays
.
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