Other Definitions
glutathione peroxidase (dict)
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Glutathione PeroxidaseThe enzyme glutathione peroxidase ( PDB 1GP1, EC 1.11.1.9) is a peroxidase found in the erythrocytes of mammals, which helps prevent lipid peroxidation of cell membranes by consuming free peroxide in the cell. The summary reaction the enzyme catalyzes is: - 2GSH + H2O2 → GSSG + 2H2O
Where GSH represents reduced monomeric glutathione, and GSSG represents oxidized glutathione. Glutathione reductase then reduces the oxidized glutathione to complete the cycle: - GSSG + NADPH + H+ → 2 GSH + NADP+
Glutathione peroxidase is a tetramer, and the bovine erythrocyte enzyme has a molecular weight of 84,000. It is a selenium containing enzyme with 4 selenocysteine amino acid residues that participate in the actual mechanism of this enzyme. See also
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