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Giant Depolarizing PotentialsGiant depolarizing potentials (GDP) are the first type of electrical activity of developing brain. These patterns of activity differ a lot from the adult brain activity patterns: they do not carry encoded information, they are generalized, they are relatively slow (with typical time of .1 s), they are repetative (with tipical time of 1s). They are, however, very different from epileptiform activity either. GDPs are slowly spreading in brain structures with a speed of approximately 1 mm/s. They use neuron's connection (axons) for this, using these connections they can develop in connected structures as well (from example from retina to geniculate nucleus). GDPs are observed only in early stages of brain development. In humans they exist only on prenatal stages, in rats they last for approximately P6. Biologycal role According to current point of view, slow developing GDPs are essential for neural nets of immature brain development. It's supposed that GDPs take the closest part in synaptogenesys, modification of synaptic connections and synapses maturation. Origin and properties One of the main conditions for GDPs development (that are met in premature brain and that aren't take place in adult one) is that GABA action on these stages should be inhibitory rather then exitatory. This, in its turn, is caused by a much higher concentration of Cl- concentration in cells cytoplasm.
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