Other Definitions
furosemide (dict)

Furosemide

bgcolor="#ffffff" align="center" colspan="2" |
Furosemide
align="center" colspan="2" | 4-chloro-N-furfuryl-
5-sulfamoylanthranilic acid
CAS number
54-31-9		 ATC code
C03CA01
bgcolor="#eeeeee" | Chemical formula bgcolor="#ddeeff" | CHClNOS
bgcolor="#eeeeee" | Molecular weight bgcolor="#ddeeff" | 330.747
bgcolor="#eeeeee" | Bioavailability bgcolor="#ddeeff" | 43-69%
bgcolor="#eeeeee" | Metabolism bgcolor="#ddeeff" | hepatic
bgcolor="#eeeeee" | Elimination half-life bgcolor="#ddeeff" | up to 100 minutes
bgcolor="#eeeeee" | Excretion bgcolor="#ddeeff" | renal 66%, biliary 33%
bgcolor="#eeeeee" | Pregnancy category bgcolor="#ddeeff" | C (Australia)
bgcolor="#eeeeee" | Legal status bgcolor="#ddeeff" | Schedule 4 (Aust)
POM (UK)
bgcolor="#eeeeee" | Routes of administration bgcolor="#ddeeff" | oral, IV, IM
Furosemide (INN) or frusemide (former BAN) is a loop diuretic used in the treatment of congestive heart failure and oedema. It is most commonly marketed by Aventis Pharma under the brand name Lasix. It has been used to prevent thoroughbred race horses from bleeding through the nose during races. Along with some other diuretics, furosemide is also included on the World Anti-Doping Agency's banned drug list due to its alleged use as a masking agent for other drugs.

Clinical use in humans

Main article: loop diuretic. Furosemide, as a loop diuretic, is principally used in the following indications (Aventis, 1998): It is also sometimes used in the management of severe hypercalcaemia in combination with adequate rehydration (Rossi, 2004).

Use in horses

Apparently, sometime in the early 1970s, furosemide's ability to prevent or at least greatly reduce the incidence of bleeding by horses during races was discovered accidentally. Pursuant to the racing rules of most states, horses that bleed from the nostrils three times are permanently barred from racing (for their own protection). Clinical trials followed, and by decade's end, racing commissions in some states began legalizing its use on race horses. On September 1, 1995, New York became the last state in the United States to approve such use, after years of refusing to consider doing so. Some states allow its use for all racehorses; some allow it only for confirmed "bleeders." Its use for this purpose is still prohibited in many other countries, however.

Brand names

Some of the brand names under which furosemide is marketed include: Aisemide®; Beronald®; Desdemin®; Discoid®; Diural®; Diurapid®; Dryptal®; Durafurid®; Errolon®; Eutensin®; Frusetic®; Frusid®; Fulsix®; Fuluvamide®; Furesis®; Furo-Puren®; Furosedon®; Hydro-rapid®; Impugan®; Katlex®; Lasilix®; Lasix®; Lowpston®; Macasirool®; Mirfat®; Nicorol®; Odemase®; Oedemex®; Profemin®; Rosemide®; Rusyde®; Trofurit®; Urex®

References

  • Aventis Pharma (1998). Lasix Approved Product Information. Lane Cove: Aventis Pharma Pty Ltd.
  • Rossi S (Ed.) (2004). Australian Medicines Handbook 2004. Adelaide: Australian Medicines Handbook. ISBN 0-9578521-4-2.

External links

 

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