Other Definitions
famotidine (dict)

Famotidine

bgcolor="#ffffff" align="center" colspan="2" |
Famotidine
align="center" colspan="2" | 3-[2-(diaminomethyleneamino)thiazol-
4-ylmethylthio]-
N-sulfamoylpropionamidine
CAS number
76824-35-6
ATC code
bgcolor="#eeeeee" | Chemical formula bgcolor="#ddeeff" | C8H15N7O2S3
bgcolor="#eeeeee" | Molecular weight bgcolor="#ddeeff" | 337.5
bgcolor="#eeeeee" | Bioavailability bgcolor="#ddeeff" | 40-45%
bgcolor="#eeeeee" | Metabolism bgcolor="#ddeeff" | hepatic
bgcolor="#eeeeee" | Elimination half-life bgcolor="#ddeeff" | 2-3.5 hours
bgcolor="#eeeeee" | Excretion bgcolor="#ddeeff" | renal
bgcolor="#eeeeee" | Pregnancy category bgcolor="#ddeeff" | B1 (Australia)
bgcolor="#eeeeee" | Legal status bgcolor="#ddeeff" | Schedule 4 (Aust)
POM (UK)
bgcolor="#eeeeee" | Routes of administration bgcolor="#ddeeff" | oral
Famotidine is a histamine H2-receptor antagonist that inhibits stomach acid production, and is commonly used in the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD). It was developed and marketed by Merck & Co. under the trade names Pepcidine and Pepcid.

Clinical use

Main article: H2-receptor antagonist

History and development

Famotidine was developed by Merck & Co., and was first marketed in 1985. The imidazole-ring of cimetidine was replaced with a 2-guanidinothiazole ring. Famotidine proved to be 30 times more active than cimetidine.

 

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