Conivaptan

bgcolor="#ffffff" align="center" colspan="2" | Conivaptan chemical structure
align="center" colspan="2" | N-(4-(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-
6(1H)-yl)carbonyl)phenyl)-
(1,1'-biphenyl)-2-carboxamide
CAS number
210101-16-9
ATC code
not yet available
bgcolor="#eeeeee" | Chemical formula bgcolor="#ddeeff" | CHNO
bgcolor="#eeeeee" | Molecular weight bgcolor="#ddeeff" | 498.583
bgcolor="#eeeeee" | Bioavailability bgcolor="#ddeeff" | N/A
bgcolor="#eeeeee" | Metabolism bgcolor="#ddeeff" | ?
bgcolor="#eeeeee" | Elimination half-life bgcolor="#ddeeff" | ?
bgcolor="#eeeeee" | Excretion bgcolor="#ddeeff" | ?
bgcolor="#eeeeee" | Pregnancy category bgcolor="#ddeeff" | ?
bgcolor="#eeeeee" | Legal status bgcolor="#ddeeff" | ?
bgcolor="#eeeeee" | Routes of administration bgcolor="#ddeeff" | Intravenous
Conivaptan (YM 087) is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). It is marketed by Yamanouchi Pharmaceutical. Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). Effectively, it causes iatrogenic nephrogenic diabetes insipidus.

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