atorvastatin

Other Definitions
atorvastatin (dict)

bgcolor="#ffffff" align="center" colspan="2" \|
align="center" colspan="2" \| R)-2-(4-fluorophenyl)-beta, delta-dihydroxy-5- (1-methylethyl)-3-phenyl-4- (phenylamino)carbonyl-1H- pyrrole-1-heptanoic acid IUPAC name*
CAS number 134523-00-5	ATC code C10AA05
bgcolor="#eeeeee" \| Chemical formula	bgcolor="#ddeeff" \| (C₃₃H₃₄FN₂O₅)₂Ca3H₂O
bgcolor="#eeeeee" \| Molecular weight	bgcolor="#ddeeff" \| 1209.42
bgcolor="#eeeeee" \| Bioavailability	bgcolor="#ddeeff" \| 12%
bgcolor="#eeeeee" \| Metabolism	bgcolor="#ddeeff" \| Liver
bgcolor="#eeeeee" \| Elimination half life	bgcolor="#ddeeff" \| 14 hours
bgcolor="#eeeeee" \| Excretion	bgcolor="#ddeeff" \| Bile
bgcolor="#eeeeee" \| Pregnancy category	bgcolor="#ddeeff" \| X (USA) D (Aust)
bgcolor="#eeeeee" \| Legal status	bgcolor="#ddeeff" \| Schedule 4 (Aust)
bgcolor="#eeeeee" \| Routes of administration	bgcolor="#ddeeff" \| oral

In medicine and pharmacology, atorvastatin (Lipitor® or atorvastatin calcium) is a member of the drug class of statins, used for lowering cholesterol and thereby preventing cardiovascular disease. Atorvastatin inhibits a rate-determining enzyme located in hepatic tissue used in cholesterol synthesis, which lowers the amount of cholesterol produced. This also has the effect of lowering the total amount of LDL cholesterol. Unlike simvastatin and pravastatin, atorvastatin is a completely synthetic compound. It is currently being marketed by the pharmaceutical company Pfizer as Lipitor.

Available forms

Atorvastatin is available as Lipitor in tablet form (10, 20, 40 or 80 mg) for oral administration. Tablets are white, elliptical, and film coated.

Mechanism of Action

Atorvastatin is a competitive inhibitor of HMG-CoA reductase. This enzyme catalyzes the reduction of 3-hydroxy-3-methylglutaryl-coenzyme A to mevalonate, which is the rate limiting step in hepatic cholesterol synthesis. Because cholesterol synthesis decreases, hepatic cells increase the number of LDL receptors on the surface of the cells, which increase the amount of LDL uptake by the hepatic cells, and decreases the amount of LDL in the blood.

References

Lipitor: Prescribing Information. (2004) Pfizer Ireland Pharmaceuticals.

External links

Manufacturer's site (lipitor.com)

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