Artemesinin
Artemesinin
is a
sesquiterpene lactone
found in Chinese
wormwood
(
Artemisia annua
). It has been used to treat
malaria
in
China
for over 1500 years. It is believed that the
endoperoxide
bridge
moiety
reacts with
heme
when the malaria
parasite
digests
red blood cells
, producing
free radicals
that
inhibit
PfATP6, a
SERCA
-type
enzyme
. Artemesinin has been shown to compete with
thapsigargin
for SERCA binding, though artemesinin is much less toxic to mammalian cells.
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