arsphenamine

Arsphenamine is a drug that was used to treat syphilis and trypanosomiasis. It was the first modern chemotherapeutic agent. Sahachiro Hata found this compound in 1908 while studying in the laboratory of Paul Ehrlich, during a survey of thousands of compounds in search of anti-spirochete activity (the bacterium that causes syphilis is a spirochete). This compound was marketed under the trade name Salvarsan in 1910. After leaving Erlich's laboratory, Hata continued parallel investigation of the new medicine in Japan. The structure is: It was the first important antisyphillitic, though was phased out in the 1930s by better arsenical compounds (neoarsphenamine), and eventually altogether by penicillin.

References

Izumi, Yoshio; and Isozumi, Kazuo. (2001). Modern Japanese medical history and the European influence. Keio Journal of Medicine 50 (2), 91-99. PMID 11450598.

<< Previous

Word Browser

Next >>

cratippus
peng chau
hadleigh
friedrich blass
hunstanton
sudbury, suffolk
scherzo
king's lynn
fulton township, pennsylvania
gap, pennsylvania
swaffham

sheringham
silverlink
national express group
the wildlife trusts partnership
gaur
naga (cocktail)
arcnet
millenarianism
fleming mcwilliams
john mark painter
the trinity broads

little red book
quotations from chairman mao zedong
benmont tench
rusty nail
brian setzer
malthouse broad
wallonia
the call (band)
ranworth broad
upton fen
alderfen broad

barton broad
cockshoot broad
hickling broad
saci
indrani
norbert zongo
marut
rudra
diti
airavata
apsara