adapalene


bgcolor="#ffffff" align="center" colspan="2" \| chemical structure
align="center" colspan="2" \| 6-3-(1-adamantyl)-4-methoxyphenyl-2-naphthoic acid
CAS number 106685-40-9	ATC code D10AD03
bgcolor="#eeeeee" \| Chemical formula	bgcolor="#ddeeff" \| C₂₈H₂₈O₃
bgcolor="#eeeeee" \| Molecular weight	bgcolor="#ddeeff" \| 412.52
bgcolor="#eeeeee" \| Bioavailability	bgcolor="#ddeeff" \| ?
bgcolor="#eeeeee" \| Metabolism	bgcolor="#ddeeff" \| ?
bgcolor="#eeeeee" \| Elimination half life	bgcolor="#ddeeff" \| ?
bgcolor="#eeeeee" \| Excretion	bgcolor="#ddeeff" \| ?
bgcolor="#eeeeee" \| Pregnancy category	bgcolor="#ddeeff" \| C
bgcolor="#eeeeee" \| Legal status	bgcolor="#ddeeff" \| ?
bgcolor="#eeeeee" \| Delivery	bgcolor="#ddeeff" \| ?

b>Indicated for:

Acne vulgaris

Recreational uses:

Unethical uses:

Other uses:

b>Contraindications:

b>Side effects:

Atypical sensations:

Cardiovascular:

Ear, nose, and throat:

Endocrinal:

Eye:

Gastrointestinal:

Hematological:

Musculo skeletal:

Neurological:

Psychological:

Respiratory:

Skin:

erythema, dryness, scaling, burning, pruritus, hypersensitivity to sunlight

Urogenital and reproductive:

Miscellaneous:

Adapalene is a chemical compound that is primarily used as a topical treatment for acne. It is a retinoid, meaning it is chemically similar to Vitamin A, and is currently sold by Galderma under the trade name Differin in many different forms. In pure form, adapalene is a white to off white powder that is insoluble in water.

History

Adapalene was approved in 1996 by the FDA for use in the treatment of acne.

Available forms

Adapalene is available in four different forms: gel, solution, pledglets and cream.

Indications

Adapalene is indicated for acne vulgaris.

Pharmacodynamics

Adapalene in small concentrations is a moderator of cellular differentiation, keratinization, and inflammatory processes. The exact mode of action of adapalene is unknown.

Pharmacokinetics

Adapalene is applied topically to the skin, and its absorption through this medium is very low. Only trace amounts of adapalene have been found in the plasma of chronically treated patients.

External link

Differin product insert

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