Achalasia

signs and symptoms

• Dysphagia
• Regurgitation of digested food
• Heartburn
• Chest pains : increases after eating and may radiate to the back, neck, and arms.
• Weight loss
• Coughing, especially at night or when lying down

Diagnosis

• X-ray with a barium swallow or esophagography . Shows narrowing at the level of the gastroesophageal junction ("bird beak"), and various degrees of megaesophagus (esophageal dilation).
• Endoscopy, which provides a view from within the esophagus.
• Manometry, the key test for establishing the diagnosis. Measures the pressure induced in different parts of the esophagus and stomach during the act of swallowing.
• CT scan, which provides further visual evidence.

Complications

1. Gastroesophageal reflux disease-GERD or heartburn.
2. Barrett's esophagus or Barrett's mucosa: in 10% of patients.
3. There are two kinds of esophageal cancer: squamous cell carcinoma and adenocarcinoma. There are predisposing conditions that, if present for a long time, may lead to esophageal adenocarcinoma, like achalasia (in up to 5% of cases, Barrett's esophagus leads to esophageal adenocarcinoma).

Treatment and new Expectations

• Balloon (pneumatic) dilation. The muscle fibers will be stretched. Gastroesophageal reflux (GERD) occurs after dilatation in 25% to 35% of patients. Is a risk to later Heller myotomy.
• Medication:
• Intra-sphincteric injection of botulinum toxin (or botox), to paralyze cardia and prevent spasms. It is transitory and symptoms will return in the majority of patients within a year.
• Drugs that reduce LES pressure such as nifedipine and nitroglycerin may be useful.
• Heller myotomy laparoscopic surgery.
• Transplant and artificial cardia.

See also

• endoscopy
• esophageal motility disorder.

External links

• International Rare Disease Support Network Email List Group for Achalasia.
• Anatomy and surgeries.
• Medlineplus.
• All about achalasia.
• U.S. National Guideline about achalasia.
• Emedicine.
• Intelihealth.
• Yahoo health encyclopedia.

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