whipple's disease

Whipple's disease is a rare disease caused by the bacteria Thropheryma whipplei. It is characterised by arthritis, malabsorption, and a number of other symptoms, most notably intestinal lipodystrophy (accumulation of fatty deposits in lymph nodes of the intestine). It was first described by George Hoyt Whipple in 1907: Whipple GH. A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acid in the intestinal and mesenteric lymphatic tissues. Bull Johns Hopkins Hosp 1907;18:382-93.

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