State> | gcolor="#cccccc"|Incumbent | bgcolor="#cccccc"|Party | bgcolor="#cccccc"|Status | bgcolor="#cccccc"|Opposing Candidates |
| a href="/encyclopedia/Alabama" title="Alabama">Alabama | Lister Hill | Democrat | Retired: Democrat victory, 70.0 - 22.1 - 8.0 | James B. Allen (Democrat) Perry Hooper (Republican) Robert Schwenn ((NDPA)) |
| a href="/encyclopedia/Alaska" title="Alaska">Alaska | Ernest Gruening | Democrat | Defeated in primary: Democrat victory, 45.1 - 37.4 - 17.4 | Mike Gravel (Democrat) Elmer Rasmuson (Republican) Ernest Gruening (Independent) |
| a href="/encyclopedia/Arizona" title="Arizona">Arizona | Carl Hayden | Democrat | Retired: Republican victory, 57.2 - 42.8 | Barry Goldwater (Republican) Roy Elson (Democrat) |
| a href="/encyclopedia/Arkansas" title="Arkansas">Arkansas | J. William Fulbright | Democrat | Re-elected, 59.2 - 40.9 | Charles Bernard (Republican) |
| a href="/encyclopedia/California" title="California">California | Thomas H. Kuchel | Republican | Retired: Democrat victory, 51.8 - 46.9 | Alan Cranston (Democrat) Max Rafferty (Republican) |
| a href="/encyclopedia/Colorado" title="Colorado">Colorado | Peter H. Dominick | Republican | Re-elected, 58.6 - 41.5 | Stephen L. R. McNichols (Democrat) |
| a href="/encyclopedia/Connecticut" title="Connecticut">Connecticut | Abraham A. Ribicoff | Democrat | Re-elected, 54.3 - 45.7 | Edwin H. May (Republican) |
| a href="/encyclopedia/Florida" title="Florida">Florida | George A. Smathers | Democrat | Retired: Republican victory, 55.9 - 44.1 | Edward J. Gurney (Republican) Leroy Collins (Democrat) |
| a href="/encyclopedia/Georgia-(U.S.-state)" title="Georgia (U.S. state)">Georgia | Herman E. Talmadge | Democrat | Re-elected, 77.5 - 22.5 | E. Earl Patton (Republican) |
| a href="/encyclopedia/Hawaii" title="Hawaii">Hawaii | Daniel K. Inouye | Democrat | Re-elected, 83.4 - 15.0 | Wayne C. Thiessen (Republican) |
| a href="/encyclopedia/Idaho" title="Idaho">Idaho | Frank Church | Democrat | Re-elected, 60.3 - 39.7 | George V. Hansen (Republican) |
| a href="/encyclopedia/Illinois" title="Illinois">Illinois | Everett M. Dirksen | Republican | Re-elected, 53.0 - 46.6 | William G. Clark (Democrat) |
| a href="/encyclopedia/Indiana" title="Indiana">Indiana | Birch Bayh | Democrat | Re-elected, 51.7 - 48.2 | William D. Ruckelshaus (Republican) |
| a href="/encyclopedia/Iowa" title="Iowa">Iowa | Bourke B. Hickenlooper | Republican | Retired: Democrat victory, 50.3 - 49.7 | Harold E. Hughes (Democrat) David M. Stanley (Republican) |
| a href="/encyclopedia/Kansas" title="Kansas">Kansas | Frank Carlson | Republican | Retired: Republican victory, 60.1 - 38.7 | Bob Dole (Republican) William I. Robinson (Democrat) |
| a href="/encyclopedia/Kentucky" title="Kentucky">Kentucky | Thruston B. Morton | Republican | Retired: Republican victory, 51.4 - 47.6 | Marlow W. Cook (Republican) Katherine Peden (Democrat) |
| a href="/encyclopedia/Louisiana" title="Louisiana">Louisiana | Russell B. Long | Democrat | Re-elected, unopposed | |
| a href="/encyclopedia/Maryland" title="Maryland">Maryland | Daniel B. Brewster | Democrat | Defeated, 47.8 - 39.1 - 13.1 | Charles Mathias, Jr. (Republican) George P. Mahoney (Independent) |
| a href="/encyclopedia/Missouri" title="Missouri">Missouri | Edward V. Long | Democrat | Retired: Democrat victory, 51.1 - 48.9 | Thomas F. Eagleton (Democrat) Thomas B. Curtis (Republican) |
| a href="/encyclopedia/Nevada" title="Nevada">Nevada | Alan Bible | Democrat | Re-elected, 54.8 - 45.2 | Ed Fike (Republican) |
| a href="/encyclopedia/New-Hampshire" title="New Hampshire">New Hampshire | Norris Cotton | Republican | Re-elected, 59.3 - 40.7 | John W. King (Democrat) |
| a href="/encyclopedia/New-York" title="New York">New York | Jacob K. Javits | Republican | Re-elected, 49.7 - 32.7 - 17.3 | Paul O'Dwyer (Democrat) James L. Buckley (Conservative) |
| a href="/encyclopedia/North-Carolina" title="North Carolina">North Carolina | Sam J. Ervin, Jr. | Democrat | Re-elected, 60.6 - 39.4 | Robert V. Somers (Republican) |
| a href="/encyclopedia/North-Dakota" title="North Dakota">North Dakota | Milton R. Young | Republican | Re-elected, 64.6 - 33.7 | Herschel Lashkowitz (Democrat) |
| a href="/encyclopedia/Ohio" title="Ohio">Ohio | Frank J. Lausche | Democrat | Retired: Republican victory, 51.5 - 48.5 | William B. Saxbe (Republican) John J. Gilligan (Democrat) |
| a href="/encyclopedia/Oklahoma" title="Oklahoma">Oklahoma | A. S. Mike Monroney | Democrat | Defeated, 51.7 - 46.2 | Henry Bellmon (Republican) |
| a href="/encyclopedia/Oregon" title="Oregon">Oregon | Wayne Morse | Democrat | Defeated, 50.2 - 49.8 | Bob Packwood (Republican) |
| a href="/encyclopedia/Pennsylvania" title="Pennsylvania">Pennsylvania | Joseph S. Clark | Democrat | Defeated, 51.9 - 45.8 | Richard S. Schweiker (Republican) |
| a href="/encyclopedia/South-Carolina" title="South Carolina">South Carolina | Ernest F. Hollings | Democrat | Re-elected, 61.9 - 38.1 | Marshall Parker (Republican) |
| a href="/encyclopedia/South-Dakota" title="South Dakota">South Dakota | George S. McGovern | Democrat | Re-elected, 56.8 - 43.2 | Archie Gubbrud (Republican) |
| a href="/encyclopedia/Utah" title="Utah">Utah | Wallace F. Bennett | Republican | Re-elected, 53.7 - 45.8 | Milton N. Wellenmann (Democrat) |
| a href="/encyclopedia/Vermont" title="Vermont">Vermont | George D. Aiken | Republican | Re-elected, 99.9 | |
| a href="/encyclopedia/Washington" title="Washington">Washington | Warren G. Magnuson | Democrat | Re-elected, 64.4 - 35.3 | Jack Metcalf (Republican) |
| a href="/encyclopedia/Wisconsin" title="Wisconsin">Wisconsin | Gaylord Nelson | Democrat | Re-elected, 61.7 - 38.3 | Jerris Leonard (Republican)
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