State> | gcolor="#cccccc"|Incumbent | bgcolor="#cccccc"|Party | bgcolor="#cccccc"|Status | bgcolor="#cccccc"|Opposing Candidates |
| a href="/encyclopedia/Arizona" title="Arizona">Arizona | Ernest W. McFarland | Democrat | Defeated, 51.3 - 48.7 | Barry Goldwater (Republican) |
| a href="/encyclopedia/California" title="California">California | William F. Knowland | Republican | Re-elected, 87.7 - 11.9 | Reuben W. Borough (Independent) |
| a href="/encyclopedia/Connecticut" title="Connecticut">Connecticut | William Benton | Democrat | Defeated, 52.5 - 44.4 | William A. Purtell (Republican) |
| a href="/encyclopedia/Connecticut" title="Connecticut">Connecticut1 | William A. Purtell | Republican | Retired: Republican victory, 51.2 - 48.5 | Prescott S. Bush (Republican) Abraham A. Ribicoff (Democrat) |
| a href="/encyclopedia/Delaware" title="Delaware">Delaware | John J. Williams | Republican | Re-elected, 54.5 - 45.5 | A. I. du Pont Bayard (Democrat) |
| a href="/encyclopedia/Florida" title="Florida">Florida | Spessard L. Holland | Democrat | Re-elected, 99.8 | |
| a href="/encyclopedia/Indiana" title="Indiana">Indiana | William E. Jenner | Republican | Re-elected, 52.4 - 46.8 | Henry F. Schrecker (Democrat) |
| a href="/encyclopedia/Kentucky" title="Kentucky">Kentucky2 | Thomas R. Underwood | Democrat | Defeated, 51.5 - 48.5 | John S. Cooper (Republican) |
| a href="/encyclopedia/Maine" title="Maine">Maine | Ralph O. Brewster | Republican | Retired: Republican victory, 58.7 - 34.9 - 6.4 | Frederick G. Payne (Republican) Roger P. Dube (Democrat) Earl S. Grant (Independent) |
| a href="/encyclopedia/Maryland" title="Maryland">Maryland | Herbert R. O'Conor | Democrat | Retired: Republican victory, 52.5 - 47.5 | James Glenn Beall (Republican) George P. Mahoney (Democrat) |
| a href="/encyclopedia/Massachusetts" title="Massachusetts">Massachusetts | Henry Cabot Lodge, Jr. | Republican | Defeated, 51.4 - 48.4 | John F. Kennedy (Democrat) |
| a href="/encyclopedia/Michigan" title="Michigan">Michigan | Blair Moody | Democrat | Defeated, 50.6 - 49.0 | Charles E. Potter (Republican) |
| a href="/encyclopedia/Minnesota" title="Minnesota">Minnesota | Edward J. Thye | Republican | Re-elected, 56.6 - 42.5 | William E. Carlson (Democrat) |
| a href="/encyclopedia/Mississippi" title="Mississippi">Mississippi | John C. Stennis | Democrat | Re-elected, unopposed | |
| a href="/encyclopedia/Missouri" title="Missouri">Missouri | James P. Kem | Republican | Defeated, 54.0 - 45.9 | Stuart Symington (Democrat) |
| a href="/encyclopedia/Montana" title="Montana">Montana | Zales N. Ecton | Republican | Defeated, 50.8 - 48.6 | Mike Mansfield (Democrat) |
| a href="/encyclopedia/Nebraska" title="Nebraska">Nebraska | Hugh Butler | Republican | Re-elected, 69.1 - 27.8 | Stanley D. Long (Democrat) |
| a href="/encyclopedia/Nebraska" title="Nebraska">Nebraska3 | Fred Andrew Seaton | Republican | Retired: Republican victory, 63.6 - 36.4 | Dwight Griswold (Republican) William Ritchie (Democrat) |
| a href="/encyclopedia/Nevada" title="Nevada">Nevada | George W. Malone | Republican | Re-elected, 51.7 - 48.3 | Thomas B. Mechling (Democrat) |
| a href="/encyclopedia/New-Jersey" title="New Jersey">New Jersey | H. Alexander Smith | Republican | Re-elected, 55.5 - 43.6 | Archibald S. Alexander (Democrat) |
| a href="/encyclopedia/New-Mexico" title="New Mexico">New Mexico | Dennis Chavez | Democrat | Re-elected, 51.1 - 48.9 | Patrick J. Hurley (Republican) |
| a href="/encyclopedia/New-York" title="New York">New York | Irving M. Ives | Republican | Re-elected, 55.2 - 36.1 - 7.0 | John Cashmore (Democrat) George S. Counts (Liberal) |
| a href="/encyclopedia/North-Dakota" title="North Dakota">North Dakota | William Langer | Republican | Re-elected, 66.4 - 23.3 - 10.4 | Harold A. Morrison (Democrat) Fred G. Aandahl (Independent) |
| a href="/encyclopedia/Ohio" title="Ohio">Ohio | John W. Bricker | Republican | Re-elected, 54.6 - 45.4 | Michael V. DiSalle (Democrat) |
| a href="/encyclopedia/Pennsylvania" title="Pennsylvania">Pennsylvania | Edward Martin | Republican | Re-elected, 51.6 - 48.0 | Guy K. Bard (Democrat) |
| a href="/encyclopedia/Rhode-Island" title="Rhode Island">Rhode Island | John O. Pastore | Democrat | Re-elected, 54.8 - 45.2 | Bayard Ewing (Republican) |
| a href="/encyclopedia/Tennessee" title="Tennessee">Tennessee | Kenneth D. McKellar | Democrat | Defeated in primary: Democrat victory, 74.2 - 20.9 | Albert Gore, Sr. (Democrat) Hobart F. Atkins (Republican) |
| a href="/encyclopedia/Texas" title="Texas">Texas | Tom Connally | Democrat | Retired: Democrat victory, unopposed | Price Daniel (Democrat) |
| a href="/encyclopedia/Utah" title="Utah">Utah | Arthur V. Watkins | Republican | Re-elected, 54.3 - 45.7 | Walter K. Granger (Democrat) |
| a href="/encyclopedia/Vermont" title="Vermont">Vermont | Ralph E. Flanders | Republican | Re-elected, 72.3 - 27.7 | Allan R. Johnston (Democrat) |
| a href="/encyclopedia/Virginia" title="Virginia">Virginia | Harry F. Byrd | Democrat | Re-elected, 73.4 - 12.7 - 12.4 | H. M. Vise, Sr. (Independent) Clarke T. Robb (Independent) |
| a href="/encyclopedia/Washington" title="Washington">Washington | Harry P. Cain | Republican | Defeated, 56.2 - 43.5 | Henry M. Jackson (Democrat) |
| a href="/encyclopedia/West-Virginia" title="West Virginia">West Virginia | Harley M. Kilgore | Democrat | Re-elected, 53.6 - 46.4 | Chapman Revercomb (Republican) |
| a href="/encyclopedia/Wisconsin" title="Wisconsin">Wisconsin | Joseph R. McCarthy | Republican | Re-elected, 54.2 - 45.6 | Thomas E. Fairchild (Democrat) |
| a href="/encyclopedia/Wyoming" title="Wyoming">Wyoming | Joseph C. O'Mahoney | Democrat | Defeated, 51.6 - 48.4 | Frank A. Barrett (Republican)
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