State> | gcolor="#cccccc"|Incumbent | bgcolor="#cccccc"|Party | bgcolor="#cccccc"|Status | bgcolor="#cccccc"|Opposing Candidates |
| a href="/encyclopedia/Alabama" title="Alabama">Alabama | Lister Hill | Democrat | Re-elected, 76.5 - 23.5 | John G. Crommelin, Jr. (Republican) |
| a href="/encyclopedia/Arizona" title="Arizona">Arizona | Carl Hayden | Democrat | Re-elected, 62.8 - 37.2 | Bruce Brockett (Republican) |
| a href="/encyclopedia/Arkansas" title="Arkansas">Arkansas | J. William Fulbright | Democrat | Re-elected, unopposed | |
| a href="/encyclopedia/California" title="California">California | Sheridan Downey | Democrat | Retired: Republican victory, 59.2 - 40.8 | Richard M. Nixon (Republican) Helen G. Douglas (Democrat) |
| a href="/encyclopedia/Colorado" title="Colorado">Colorado | Eugene D. Millikin | Republican | Re-elected, 53.3 - 46.8 | John A. Carroll (Democrat) |
| a href="/encyclopedia/Connecticut" title="Connecticut">Connecticut1 | William Benton | Democrat | Re-elected, 49.2 - 49.1 | Prescott S. Bush (Republican) |
| a href="/encyclopedia/Connecticut" title="Connecticut">Connecticut | Brien McMahon | Democrat | Re-elected, 51.7 - 46.6 | Joseph E. Talbot (Republican) |
| a href="/encyclopedia/Florida" title="Florida">Florida | Claude Pepper | Democrat | Defeated in primary: Democrat victory, 76.2 - 23.7 | George A. Smathers (Democrat) John P. Booth (Republican) |
| a href="/encyclopedia/Georgia-(U.S.-state)" title="Georgia (U.S. state)">Georgia | Walter F. George | Democrat | Re-elected, unopposed | |
| a href="/encyclopedia/Idaho" title="Idaho">Idaho | Glen H. Taylor | Democrat | Retired: Republican victory, 61.7 - 38.3 | Herman Welker (Republican) D. Worth Clark (Democrat) |
| a href="/encyclopedia/Idaho" title="Idaho">Idaho2 | Henry C. Dworshak | Republican | Re-elected, 51.9 - 48.1 | Claude J. Burtenshaw (Democrat) |
| a href="/encyclopedia/Illinois" title="Illinois">Illinois | Scott W. Lucas | Democrat | Defeated, 53.9 - 45.8 | Everett M. Dirksen (Republican) |
| a href="/encyclopedia/Indiana" title="Indiana">Indiana | Homer E. Capehart | Republican | Re-elected, 52.8 - 46.4 | Alex M. Campbell (Democrat) |
| a href="/encyclopedia/Iowa" title="Iowa">Iowa | Bourke B. Hickenlooper | Republican | Re-elected, 54.8 - 44.7 | Albert J. Loveland (Democrat) |
| a href="/encyclopedia/Kansas" title="Kansas">Kansas | Frank Carlson | Republican | Re-elected, 54.3 - 43.8 | Paul Aiken (Democrat) |
| a href="/encyclopedia/Kentucky" title="Kentucky">Kentucky | Earle C. Clements | Democrat | Re-elected, 54.2 - 45.1 | Charles I. Dawson (Republican) |
| a href="/encyclopedia/Louisiana" title="Louisiana">Louisiana | Russell B. Long | Democrat | Re-elected, 87.7 - 12.3 | Charles S. Gerth (Republican) |
| a href="/encyclopedia/Maryland" title="Maryland">Maryland | Millard E. Tydings | Democrat | Defeated, 53.0 - 46.0 | John M. Butler (Republican) |
| a href="/encyclopedia/Missouri" title="Missouri">Missouri | Forrest C. Donnell | Republican | Defeated, 53.6 - 46.4 | Thomas C. Hennings, Jr. (Democrat) |
| a href="/encyclopedia/Nevada" title="Nevada">Nevada | Patrick A. McCarran | Democrat | Re-elected, 58.0 - 42.0 | George E. Marshall (Republican) |
| a href="/encyclopedia/New-Hampshire" title="New Hampshire">New Hampshire | Charles W. Tobey | Republican | Re-elected, 55.7 - 38.0 - 6.3 | Emmet J. Kelley (Democrat) Wesley Powell (Independent) |
| a href="/encyclopedia/New-York" title="New York">New York | Herbert H. Lehman | Democrat | Re-elected, 50.3 - 45.3 | Joe R. Hanley (Republican) |
| a href="/encyclopedia/North-Carolina" title="North Carolina">North Carolina3 | Frank Porter Graham | Democrat | Defeated in primary: Democrat victory, 67.0 - 32.6 | Willis Smith (Democrat) E. L. Gavin (Republican) |
| a href="/encyclopedia/North-Carolina" title="North Carolina">North Carolina | Clyde R. Hoey | Democrat | Re-elected, 68.7 - 31.3 | Halsey B. Leavitt (Republican) |
| a href="/encyclopedia/North-Dakota" title="North Dakota">North Dakota | Milton R. Young | Republican | Re-elected, 67.6 - 32.4 | Harry O'Brien (Democrat) |
| a href="/encyclopedia/Ohio" title="Ohio">Ohio | Robert A. Taft | Republican | Re-elected, 57.5 - 42.5 | Joseph T. Ferguson (Democrat) |
| a href="/encyclopedia/Oklahoma" title="Oklahoma">Oklahoma | Elmer Thomas | Democrat | Retired: Democrat victory, 54.8 - 45.2 | A. S. Mike Monroney (Democrat) W. H. Bill Alexander (Republican) |
| a href="/encyclopedia/Oregon" title="Oregon">Oregon | Wayne Morse | Republican | Re-elected, 74.8 - 23.2 | Howard Latourette (Democrat) |
| a href="/encyclopedia/Pennsylvania" title="Pennsylvania">Pennsylvania | Francis J. Myers | Democrat | Defeated, 51.3 - 47.7 | James H. Duff (Republican) |
| a href="/encyclopedia/Rhode-Island" title="Rhode Island">Rhode Island4 | Edward L. Leahy | Democrat | Retired: Democrat victory, 61.6 - 38.4 | John O. Pastore (Democrat) Austin T. Levy (Republican) |
| a href="/encyclopedia/South-Carolina" title="South Carolina">South Carolina | Olin B. Johnston | Democrat | Re-elected, unopposed | |
| a href="/encyclopedia/South-Dakota" title="South Dakota">South Dakota | Chandler Gurney | Republican | Retired: Republican victory, 63.9 - 36.1 | Francis Case (Republican) John A. Engel (Democrat) |
| a href="/encyclopedia/Utah" title="Utah">Utah | Elbert D. Thomas | Democrat | Defeated, 53.9 - 45.8 | Wallace F. Bennett (Republican) |
| a href="/encyclopedia/Vermont" title="Vermont">Vermont | George D. Aiken | Republican | Re-elected, 78.0 - 22.0 | James E. Bigelow (Democrat) |
| a href="/encyclopedia/Washington" title="Washington">Washington | Warren G. Magnuson | Democrat | Re-elected, 53.4 - 46.0 | Walter Williams (Republican) |
| a href="/encyclopedia/Wisconsin" title="Wisconsin">Wisconsin | Alexander Wiley | Republican | Re-elected, 53.3 - 46.2 | Thomas E. Fairchild (Democrat)
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