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U.s. Highway 281United States Highway 281 is a north-south United States highway. Termini The highway's northern terminus is at the International Peace Garden, north of Dunseith, North Dakota at the Canadian border, where it continues as Manitoba Provincial Highway 10. The route between Dunseith and the border is shared with North Dakota Highway 3. The southern terminus of US 281 is in Brownsville, Texas, just short of the Mexican border. States Traversed The highway passes through the following states: Major Cities Major cities along the route include: Intersections US 281 Intersects with the following Interstate Highways: - Interstate 94 in Jamestown, North Dakota
- Interstate 90 near Plankinton, South Dakota
- Interstate 80 in Grand Island, Nebraska
- Interstate 70 in Russell, Kansas
- Interstate 40 in Hinton, Oklahoma
- Interstates 10, 410, 35, and 37 in San Antonio, Texas
- Interstate 37 between Pleasanton and Three Rivers, Texas (shared route)
Related US Routes 281 81-2 81-2 81-2
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