Sigma Factor

Sigma factor (σ factor) is an initiation factor that binds to RNA polymerase and promotes attachment to promoter sites on DNA.

Structure

Sigma factor has four main regions: N----------C
  1  2  3  4 
  • Region 1 regulates interaction with DNA.
  • Region 2 binds RNAP and binds to the -10 promoter site.
  • Region 4 binds to the -35 promoter site.

 

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