| b>Player | HR |
| a href="/encyclopedia/Babe-Ruth" title="Babe Ruth">Babe Ruth | 49 |
| a href="/encyclopedia/Earl-Wilson" title="Earl Wilson">Earl Wilson | 44 |
| a href="/encyclopedia/Wes-Ferrell" title="Wes Ferrell">Wes Ferrell | 40 |
| a href="/encyclopedia/Red-Ruffing" title="Red Ruffing">Red Ruffing | 40 |
| a href="/encyclopedia/Bob-Lemon" title="Bob Lemon">Bob Lemon | 37 |
| a href="/encyclopedia/Warren-Spahn" title="Warren Spahn">Warren Spahn | 35 |
| a href="/encyclopedia/Jack-Stivetts" title="Jack Stivetts">Jack Stivetts | 33 |
| a href="/encyclopedia/Dave-Foutz" title="Dave Foutz">Dave Foutz | 31 |
| a href="/encyclopedia/Jimmy-Ryan-(baseball-player)" title="Jimmy Ryan (baseball player)">Jimmy Ryan | 31 |
| a href="/encyclopedia/Don-Drysdale" title="Don Drysdale">Don Drysdale | 29 |
| a href="/encyclopedia/George-Van-Haltren" title="George Van Haltren">George Van Haltren | 28 |
| a href="/encyclopedia/Bob-Caruthers" title="Bob Caruthers">Bob Caruthers | 28 |
| a href="/encyclopedia/John-Clarkson" title="John Clarkson">John Clarkson | 25 |
| a href="/encyclopedia/Bob-Gibson" title="Bob Gibson">Bob Gibson | 24 |
| a href="/encyclopedia/Walter-Johnson" title="Walter Johnson">Walter Johnson | 24 |
| a href="/encyclopedia/Milt-Pappas" title="Milt Pappas">Milt Pappas | 23 |
| a href="/encyclopedia/Jim-Tobin" title="Jim Tobin">Jim Tobin | 22 |
| a href="/encyclopedia/Jack-Harshman" title="Jack Harshman">Jack Harshman | 21 |
| a href="/encyclopedia/Dizzy-Trout" title="Dizzy Trout">Dizzy Trout | 21 |
| a href="/encyclopedia/Don-Cardwell" title="Don Cardwell">Don Cardwell | 20 |
| a href="/encyclopedia/Oyster-Burns" title="Oyster Burns">Oyster Burns | 20 |
| || || |