| colspan=6 | Continued from List of human spaceflights, 1987-1999 |
| Name | Launch
Vehicle | colspan=2 | Habitation | Return
Vehicle | Brief Mission Summary |
Kevin R. Kregel
Dominic L. Gorie
Janet L. Kavandi
Janice E. Voss
Mamoru Mohri
Gerhard P.J. Thiele | colspan=2 | 11 February 2000
STS-99, Endeavour | colspan=2 | 22 February 2000
STS-99, Endeavour | |
Sergei Zalyotin
Alexander Kaleri | 6 April 2000
Soyuz TM-30 | colspan=2 | Mir | 16 June 2000
Soyuz TM-30 | |
James D. Halsell
Scott J. Horowitz
Mary Weber
Jeffrey N. Williams
Susan J. Helms
Yuri Usachev | colspan=2 | 19 May 2000
STS-101, Atlantis | colspan=2 | 29 May 2000
STS-101, Atlantis | |
Terrence W. Wilcutt
Scott D. Altman
Daniel C. Burbank
Edward T. Lu
Richard A. Mastracchio
Yuri I. Malenchenko
Boris V. Morukov | colspan=2 | 8 September 2000
STS-106, Atlantis | colspan=2 | 19 September 2000
STS-106, Atlantis | |
Brian Duffy
Pamela A. Melroy
Koichi Wakata
Leroy Chiao
Peter J.K. Wisoff
Michael Lopez-Alegria
William S. McArthur | colspan=2 | 11 October 2000
STS-92, Discovery | colspan=2 | 24 October 2000
STS-92, Discovery | |
William Shepherd
Yuri Gidzenko
Sergei Krikalev | 31 October 2000
Soyuz TM-31 | colspan=2 | ISS
(crew 1) | 21 March 2001
STS-102, Discovery | |
Brent Jett
Michael J. Bloomfield
Joseph Tanner
Marc Garneau
Carlos I. Noriega | colspan=2 | 30 November 2000
STS-97, Endeavour | colspan=2 | 11 December 2000
STS-97, Endeavour | |
Kenneth Cockrell
Mark Polansky
Robert Curbeam
Thomas Jones
Marsha Ivins | colspan=2 | 7 February 2001
STS-98, Atlantis | colspan=2 | 20 February 2001
STS-98, Atlantis | |
James Wetherbee
James Kelly
Andy Thomas
Paul W. Richards | rowspan=2 | 8 March 2001
STS-102, Discovery | colspan=2 | ISS | 21 March 2001
STS-102, Discovery | |
Yury Usachev
James Voss
Susan Helms | colspan=2 | ISS
(crew 2) | 22 August 2001
STS-105, Discovery | |
Talgat Musabayev
Yuri Baturin
Dennis Tito | 29 April 2001
Soyuz TM-32 | colspan=2 | ISS | 5 May 2001
Soyuz TM-31 | |
Kent Rominger
Jeffrey Ashby
Chris Hadfield
Scott Parazynski
John Phillips
Umberto Guidoni
Yuri Lonchakov | colspan=2 | 19 April 2001
STS-100, Endeavour | colspan=2 | 1 May 2001
STS-100, Endeavour | |
Steven Lindsey
Charles Hobaugh
Michael Gernhardt
James Reilly
Janet Kavandi | colspan=2 | 12 July 2001
STS-104, Atlantis | colspan=2 | 24 July 2001
STS-104, Atlantis | |
Scott Horowitz
Frederick Sturckow
Daniel Barry
Patrick Forrester | rowspan=2 | 10 August 2001
STS-105, Discovery | colspan=2 | ISS | 22 August 2001
STS-105, Discovery | |
Frank L. Culbertson, Jr.
Vladimir Dezhurov
Mikhail Tyurin | colspan=2 | ISS
(crew 3) | 17 December 2001
STS-108, Endeavour | |
Victor Afanasyev
Konstantin Kozeev
Claudie Haignere | 21 October 2001
Soyuz TM-33 | colspan=2 | ISS | 31 October 2001
Soyuz TM-32 | |
Dominic L. Gorie
Mark E. Kelly
Linda M. Godwin
Daniel M. Tani | rowspan=2 | 5 December 2001
STS-108, Endeavour | colspan=2 | ISS | 17 December 2001
STS-108, Endeavour | |
Yuri I. Onufrienko
Carl E. Walz
Daniel W. Bursch | colspan=2 | ISS
(crew 4) | 19 June 2002
STS-111, Endeavour | |
Scott D. Altman
Duane G. Carey
John M. Grunsfeld
Nancy J. Currie
James H. Newman
Richard M. Linnehan
Michael J. Massimino | colspan=2 | 1 March 2002
STS-109, Columbia | colspan=2 | 12 March 2002
STS-109, Columbia | |
Michael J. Bloomfield
Stephen N. Frick
Jerry L. Ross
Steven L. Smith
Ellen Ochoa
Lee M.E. Morin
Rex J. Walheim | colspan=2 | 8 April 2002
STS-110, Atlantis | colspan=2 | 19 April 2002
STS-110, Atlantis | |
Yuri Gidzenko
Roberto Vittori
Mark Shuttleworth | 25 April 2002
Soyuz TM-34 | colspan=2 | ISS | 5 May 2002
Soyuz TM-33 | |
Kenneth Cockrell
Paul Lockhart
Franklin Chang-Diaz
Philippe Perrin | rowspan=2 | 5 June 2002
STS-111, Endeavour | colspan=2 | ISS | 19 June 2002
STS-111, Endeavour | |
Valeri Korzun
Peggy Whitson
Sergei Treschev | colspan=2 | ISS
(crew 5) | 7 December 2002
STS-113, Endeavour | |
Jeffrey Ashby
Pamela Melroy
David Wolf
Piers Sellers
Sandra Magnus
Fyodor Yurchikhin | colspan=2 | 7 October 2002
STS-112, Atlantis | colspan=2 | 18 October 2002
STS-112, Atlantis | |
Sergei Zalyotin
Yuri Lonchakov
Frank De Winne | 29 October 2002
Soyuz TMA-1 | colspan=2 | ISS | 10 November 2002
Soyuz TM-34 | |
Jim Wetherbee
Paul Lockhart
Michael Lopez-Alegria
John Herrington | rowspan=2 | 23 November 2002
STS-113, Endeavour | colspan=2 | ISS | 7 December 2002
STS-113, Endeavour | |
Nikolai Budarin
Ken Bowersox
Donald Pettit | colspan=2 | ISS
(crew 6) | 4 May 2003 Soyuz TMA-1 | |
Rick Husband
Willie McCool
Michael Anderson
Kalpana Chawla
David Brown
Laurel Clark
Ilan Ramon | colspan=2 | 16 January 2003
STS-107, Columbia | colspan=2 | 1 February 2003
STS-107, Columbia | Lost during re-entry. |
Yuri Malenchenko
Ed Lu | 25 April 2003
Soyuz TMA-2 | colspan=2 | ISS
(crew 7) | 27 October 2003
Soyuz TMA-2 | |
| Yang Liwei | colspan=4 | 15 October 2003
Shenzhou 5 | First Chinese spaceflight. |
| Pedro Duque | rowspan=2 | 18 October 2003
Soyuz TMA-3 | colspan=2 | ISS | 27 October 2003
Soyuz TMA-2 | |
Michael Foale
Alexandr Kaleri | colspan=2 | ISS
(crew 8) | 29 April 2004
Soyuz TMA-3 | |
| Andre Kuipers | rowspan=2 | 19 April 2004
Soyuz TMA-4 | colspan=2 | ISS |
29 April 2004
Soyuz TMA-3 | |
Edward Fincke
Gennady Padalka | colspan=2 | ISS
(crew 9) | October 24, 2004
Soyuz TMA-4 | |
| Mike Melvill | colspan=4 | 21 June 2004
SpaceShipOne flight 15P | First commercial human spaceflight |
| Mike Melvill | colspan=4 | 29 September 2004
SpaceShipOne flight 16P | Ansari X Prize flight #1 |
| Brian Binnie | colspan=4 | October 4 2004
SpaceShipOne flight 17P | Ansari X Prize flight #2, winning the prize |
| Yuri Shargin | rowspan=2 | October 14 2004
Soyuz TMA-5 | colspan=2 | ISS |
October 24, 2004
Soyuz TMA-4 | |
Salizhan Sharipov
Leroy Chiao | colspan=2 | ISS
(crew 10) | Still in orbit | |