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Gene OntologyThe Gene Ontology, or GO, is a trio of controlled vocabularies that are being developed to aid the description of the molecular functions of gene products, their placement in and as cellular components, and their participation in biological processes. Terms in each of the vocabularies are related to one another within a vocabulary in a polyhierarchical (or directed acyclic graph) manner; terms are mutually exclusive across the three vocabularies. Each term consists of a definition, an alphanumerical identifier, and a phrase (the term itself). The Gene Ontology originated from the efforts of a consortium of model organism genome sequencing and annotation groups and the contributory efforts have multiplied as an ever increasing amount of genome product annotation has taken place from the late 1990's to today. There is a significant body of literature on the development and use of the GO and it has become a standard tool in the bioinformatics arsenal. The GO is part of a larger group of vocabularies, the Open Biomedical Ontologies or OBO. External Links Home site for the Gene Ontology Consortium, providing access to the Ontologies, software tools, annotated gene products lists, references both about and about the use of the GO, among other resources.
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