demeclocycline

bgcolor="#ffffff" align="center" colspan="2" \| Demeclocycline
align="center" colspan="2" \| 7-chloro-4-(dimethylamino)- 1,4,4a,5,5a,6,11,12a-octahydro- 3,6,10,12,12a-pentahydroxy-1,11-dioxo-, (4S,4aS,5aS,6S,12aS)-2-naphthacenecarboxamide
CAS number 127-33-3 or 64-73-3 (HCl)	ATC code D06AA01 and J01AA01
bgcolor="#eeeeee" \| Chemical formula	bgcolor="#ddeeff" \| CHClNO
bgcolor="#eeeeee" \| Molecular weight	bgcolor="#ddeeff" \| 464.856
bgcolor="#eeeeee" \| Bioavailability	bgcolor="#ddeeff" \| ?
bgcolor="#eeeeee" \| Metabolism	bgcolor="#ddeeff" \| ?
bgcolor="#eeeeee" \| Elimination half-life	bgcolor="#ddeeff" \| ?
bgcolor="#eeeeee" \| Excretion	bgcolor="#ddeeff" \| ?
bgcolor="#eeeeee" \| Pregnancy category	bgcolor="#ddeeff" \| ?
bgcolor="#eeeeee" \| Legal status	bgcolor="#ddeeff" \| ?
bgcolor="#eeeeee" \| Routes of administration	bgcolor="#ddeeff" \| Oral 150 mg/300 mg

Demeclocycline (marketed as Declomycin®, Declostatin® and Ledermycin®) is a tetracycline antibiotic used in various types of bacterial infections. One of its other registered uses is the treatment of hyponatremia (low blood sodium concentration) due to the syndrome of inappropriate antidiuretic hormone (SIADH) where fluid restriction alone has been ineffective. It is derived from the Streptomyces aureofaciens fungal strain.

Mode of action

Its use as an antibiotic is particularly in Lyme disease, acne and bronchitis. Resistance is gradually becoming more common. As with related tetracycline antibiotics, demeclocycline acts by binding to the 30S- and 50S-RNA, which impairs protein synthesis by bacteria. It is therefore bacteriostatic (it impairs bacterial growth but does not kill bacteria directly). Demeclocycline is rarely used for infections. The use in SIADH actually relies on a side-effect of tetracycline antibiotics; many may cause diabetes insipidus (dehydration due to the inability to concentrate urine). It is not completely understood why demeclocycline impairs the action of antidiuretic hormone, but it is thought that it blocks the binding of the hormone to its receptor.

Side-effects and interactions

These are similar to other tetracyclines. Hypersensitivity may occur. Skin reactions with sunlight have been reported.

Contraindications

As other tetracyclines, demeclocycline is contraindicated in children and pregnant or nursing women. All members of this class interfere with bone development and may discolour teeth.

<< Previous

Word Browser

Next >>

shizuo imaizumi
lucio cabaas
jay carsey
finchley road
mary carleton
jukka ammondt
democratic progressive party (singapore)
henri rol tanguy
boyne river bridge
cairnlea, victoria
kokikai

shuji maruyama
liddy holloway
omega trust
shin budo kai
eileen derbyshire
caesar st. augustine de buonaparte
luther and johnny htoo
vampirebuster
nippon kan
ghostbuster
arizona canal

london monster
coorparoo, queensland
geert jan jansen
alhambra centre
puppet master (movie)
ice palace
dead this year, dead career, or allegedly queer
spawn of possession
barnsley market
cocoroc, victoria
mina harker

fibrous cap
emotional abuse
rodney skinner
purushamedha
evgeny zarafiants
rat bike
bill lekas book club
diamond hill (mtr)
food sensitivity
bordj bou arreridj
loft