dna ligase

In molecular biology, DNA ligase is an enzyme that repairs broken DNA strands. DNA ligase (EC 6.5.1.1) is a particular type of enzyme that can form covalent phosphodiester bonds and ligate or connect (broken) DNA strands. An example of how a ligase works (with sticky ends):

  5'-AGTCTGATCTGACT        GATGCGTATGCTAGTGCT-3'  3'-TCAGACTAGACTGACTACG        CATACGATCACGA-5'

becomes

  5'-AGTCTGATCTGACTGATGCGTATGCTAGTGCT-3'  3'-TCAGACTAGACTGACTACGCATACGATCACGA-5'

External links

DNA Ligase: PDB molecule of the month

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