| Route | Name | Interstate predecessor | Terminus | Maxiumim speed limit | Comments |
| PR-22 | Autopista Jos de Diego | PR-2 | Hatillo, PR-2 to San Juan, PR-18 | 65 MPH | Extension to Aguadilla planned for completion in 2008 |
| PR-52 | Autopista Luis A. Ferr | PR-1 | Ponce, PR-2 to Caguas, PR-1 | 70 MPH | None |
| PR-53 | Autopista Dr. Jos Celso Barbosa | PR-3 | Ceiba/Roosevelt Roads Naval Air Station to Yabucoa, PR-191 | 60 MPH | Extension to Guayama planned for completion in 2008 |
| PR-66 | Corredor del Este | PR-3 | Carolina, PR-2 to Ro Grande, PR-1967 | Unknown | Proposed |