A50 Road

• The centre of Warrington via Junction 20 of the M6, Knutsford, Holmes Chapel, Kidsgrove and Stoke on Trent to Junction 24A the M1 near Kegworth via Derby's southern bypass. From Stoke to Derby was originally planned to be the M64.
• Junction 22 of the M1 to the centre of the City of Leicester which is its southernmost point.

• The section from Leicester to Northampton is now designated the A5199 having been down-classified when the A14 was built to deter drivers from assuming it was a high-grade road, which it is not.

• The section south of Northampton was down-classified when the M1 was built as it runs parallel with the motorway and is an unsuitable alternative.
• Between Northampton and Newport Pagnell it is now the B526.
• From Newport Pagnell to Woburn it is the A5130 save for a stretch between Newport Pagnell and Junction 14 of the M1.
• From Woburn to Hockcliffe it is the A4012.

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