280 Bc

• Battle of Heraclea: The Greeks, led by Pyrrhus of Epirus, defeat with severe casualties a Roman army the first time these cultures meet in battle.
• Aristarchus uses the size of the Earth's shadow on the Moon to estimate that the Moon's radius is one-third that of the Earth.
• Achaean League refounded.

• Philon of Byzantium
• Li Si (approximate date)

• Herophilus
• Seleucus I Nicator

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