indispose - cause to feel unwell; "She was indisposed"

exhaust, tucker, tucker out, wash up, beat - wear out completely; "This kind of work exhausts me"; "I'm beat"; "He was all washed up after the exam"

overfatigue, overtire, overweary - tire excessively

degenerate, deteriorate, devolve, drop - grow worse; "Her condition deteriorated"; "Conditions in the slums degenerated"; "The discussion devolved into a shouting match"

poop out, conk out, peter out, run down, run out - use up all one's strength and energy and stop working; "At the end of the march, I pooped out"

retire, withdraw - lose interest; "he retired from life when his wife died"

tired - depleted of strength or energy; "tired mothers with crying babies"; "too tired to eat"