midbrain - the middle portion of the brainbrain, encephalon - that part of the central nervous system that includes all the higher nervous centers; enclosed within the skull; continuous with the spinal cord locus niger, nucleus niger, substantia nigra - a layer of deeply pigmented gray matter in the midbrain; associated with the striate body; is involved in metabolic disturbances associated with Parkinson's disease and with Huntington's disease |