shape, determine, influence, regulate, mold - shape or influence; give direction to; "experience often determines ability"; "mold public opinion"

alter, change, modify - cause to change; make different; cause a transformation; "The advent of the automobile may have altered the growth pattern of the city"; "The discussion has changed my thinking about the issue"

hurt - give trouble or pain to; "This exercise will hurt your back"

constipate, bind - cause to be constipated; "These foods tend to constipate you"

fag out, wear down, wear out, wear upon, weary, tire out, fatigue, jade, outwear, tire, fag, wear - exhaust or tire through overuse or great strain or stress; "We wore ourselves out on this hike"

alter, change, modify - cause to change; make different; cause a transformation; "The advent of the automobile may have altered the growth pattern of the city"; "The discussion has changed my thinking about the issue"