ill-being - lack of prosperity or happiness or health

bad luck, ill luck, tough luck, misfortune - an unfortunate state resulting from unfavorable outcomes

disaster, catastrophe - a state of extreme (usually irremediable) ruin and misfortune; "lack of funds has resulted in a catastrophe for our school system"; "his policies were a disaster"

extremity - an extreme condition or state (especially of adversity or disease)

distress - a state of adversity (danger or affliction or need); "a ship in distress"; "she was the classic maiden in distress"

affliction - a state of great suffering and distress due to adversity

victimization - adversity resulting from being made a victim; "his victimization infuriated him"

low-water mark, nadir - an extreme state of adversity; the lowest point of anything

difficultness, difficulty - the quality of being difficult; "they agreed about the difficulty of the climb"

misfortune, bad luck - unnecessary and unforeseen trouble resulting from an unfortunate event