irritate - excite to an abnormal condition, of chafe or inflame; "Aspirin irritates my stomach"

inflame - cause inflammation in; "The repetitive motion inflamed her joint"

alter, change, modify - cause to change; make different; cause a transformation; "The advent of the automobile may have altered the growth pattern of the city"; "The discussion has changed my thinking about the issue"

cheapen, degrade - lower the grade of something; reduce its worth

anger - make angry; "The news angered him"