disturbance, perturbation - activity that is an intrusion or interruption; "he looked around for the source of the disturbance"; "there was a disturbance of neural function"

negative stimulus - a stimulus with undesirable consequences

nuisance - (law) a broad legal concept including anything that disturbs the reasonable use of your property or endangers life and health or is offensive

irritant, thorn - something that causes irritation and annoyance; "he's a thorn in my flesh"

plague - an annoyance; "those children are a damn plague"

strain, strive, reach - to exert much effort or energy; "straining our ears to hear"

get under one's skin, get - irritate; "Her childish behavior really get to me"; "His lying really gets me"

eat into, rankle, grate, fret - gnaw into; make resentful or angry; "The unjustice rankled her"; "his resentment festered"

chafe - feel extreme irritation or anger; "He was chafing at her suggestion that he stay at home while she went on a vacation"

peeve - cause to be annoyed, irritated, or resentful

ruffle - trouble or vex; "ruffle somebody's composure"

fret - cause annoyance in

beset, chevvy, chevy, chivvy, chivy, harass, harry, hassle, molest, plague, provoke - annoy continually or chronically; "He is known to harry his staff when he is overworked"; "This man harasses his female co-workers"

antagonize, antagonise - provoke the hostility of; "Don't antagonize your boss"

displease - give displeasure to

affect, bear upon, impact, bear on, touch on, touch - have an effect upon; "Will the new rules affect me?"

intrude, irrupt - enter uninvited; "They intruded on our dinner party"; "She irrupted into our sitting room"

charge up, commove, agitate, rouse, turn on, excite, charge - cause to be agitated, excited, or roused; "The speaker charged up the crowd with his inflammatory remarks"

bother - make confused or perplexed or puzzled

disconcert, flurry, confuse, put off - cause to feel embarrassment; "The constant attention of the young man confused her"

bother - make nervous or agitated; "The mere thought of her bothered him and made his heart beat faster"