discomfit, discompose, untune, upset, disconcert - cause to lose one's composure

aggrieve, grieve - break the heart of; cause to feel sorrow

tribulate - oppress or trouble greatly

strain, stress, try - test the limits of; "You are trying my patience!"

damage - inflict damage upon; "The snow damaged the roof"; "She damaged the car when she hit the tree"

visit - assail; "He was visited with a terrible illness that killed him quickly"

blight, plague - cause to suffer a blight; "Too much rain may blight the garden with mold"

hurt - give trouble or pain to; "This exercise will hurt your back"

disagree with - be note very well digestible; "Spicy food disagrees with some people"

recrudesce, break out, erupt - become raw or open; "He broke out in hives"; "My skin breaks out when I eat strawberries"; "Such boils tend to recrudesce"